Binding of Telomestatin, TMPyP4, BSU6037, and BRACO19 to a Telomeric G-Quadruplex–Duplex Hybrid Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent

[Image: see text] A promising anticancer therapeutic strategy is the stabilization of telomeric G-quadruplexes using G-quadruplex-binding small molecules. Although many G-quadruplex-specific ligands have been developed, their low potency and selectivity to G-quadruplexes over duplex remains unsolved...

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Detalles Bibliográficos
Autores principales: Sullivan, Holli-Joi, Readmond, Carolyn, Radicella, Christina, Persad, Victoria, Fasano, Thomas J., Wu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289566/
https://www.ncbi.nlm.nih.gov/pubmed/30555989
http://dx.doi.org/10.1021/acsomega.8b01574

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