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Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the C...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289573/ https://www.ncbi.nlm.nih.gov/pubmed/30526854 http://dx.doi.org/10.7554/eLife.40247 |
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author | Miroschnikow, Anton Schlegel, Philipp Schoofs, Andreas Hueckesfeld, Sebastian Li, Feng Schneider-Mizell, Casey M Fetter, Richard D Truman, James W Cardona, Albert Pankratz, Michael J |
author_facet | Miroschnikow, Anton Schlegel, Philipp Schoofs, Andreas Hueckesfeld, Sebastian Li, Feng Schneider-Mizell, Casey M Fetter, Richard D Truman, James W Cardona, Albert Pankratz, Michael J |
author_sort | Miroschnikow, Anton |
collection | PubMed |
description | We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the CNS. Output neurons consist of feeding motor, serotonergic modulatory and neuroendocrine neurons. Monosynaptic connections from a set of sensory synaptic compartments cover the motor, modulatory and neuroendocrine targets in overlapping domains. Polysynaptic routes are superimposed on top of monosynaptic connections, resulting in divergent sensory paths that converge on common outputs. A completely different set of sensory compartments is connected to the mushroom body calyx. The mushroom body output neurons are connected to interneurons that directly target the feeding output neurons. Our results illustrate a circuit architecture in which monosynaptic and multisynaptic connections from sensory inputs traverse onto output neurons via a series of converging paths. |
format | Online Article Text |
id | pubmed-6289573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62895732018-12-12 Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome Miroschnikow, Anton Schlegel, Philipp Schoofs, Andreas Hueckesfeld, Sebastian Li, Feng Schneider-Mizell, Casey M Fetter, Richard D Truman, James W Cardona, Albert Pankratz, Michael J eLife Neuroscience We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the CNS. Output neurons consist of feeding motor, serotonergic modulatory and neuroendocrine neurons. Monosynaptic connections from a set of sensory synaptic compartments cover the motor, modulatory and neuroendocrine targets in overlapping domains. Polysynaptic routes are superimposed on top of monosynaptic connections, resulting in divergent sensory paths that converge on common outputs. A completely different set of sensory compartments is connected to the mushroom body calyx. The mushroom body output neurons are connected to interneurons that directly target the feeding output neurons. Our results illustrate a circuit architecture in which monosynaptic and multisynaptic connections from sensory inputs traverse onto output neurons via a series of converging paths. eLife Sciences Publications, Ltd 2018-12-11 /pmc/articles/PMC6289573/ /pubmed/30526854 http://dx.doi.org/10.7554/eLife.40247 Text en © 2018, Miroschnikow et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Miroschnikow, Anton Schlegel, Philipp Schoofs, Andreas Hueckesfeld, Sebastian Li, Feng Schneider-Mizell, Casey M Fetter, Richard D Truman, James W Cardona, Albert Pankratz, Michael J Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome |
title | Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome |
title_full | Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome |
title_fullStr | Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome |
title_full_unstemmed | Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome |
title_short | Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome |
title_sort | convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a drosophila feeding connectome |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289573/ https://www.ncbi.nlm.nih.gov/pubmed/30526854 http://dx.doi.org/10.7554/eLife.40247 |
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