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Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome

We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the C...

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Autores principales: Miroschnikow, Anton, Schlegel, Philipp, Schoofs, Andreas, Hueckesfeld, Sebastian, Li, Feng, Schneider-Mizell, Casey M, Fetter, Richard D, Truman, James W, Cardona, Albert, Pankratz, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289573/
https://www.ncbi.nlm.nih.gov/pubmed/30526854
http://dx.doi.org/10.7554/eLife.40247
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author Miroschnikow, Anton
Schlegel, Philipp
Schoofs, Andreas
Hueckesfeld, Sebastian
Li, Feng
Schneider-Mizell, Casey M
Fetter, Richard D
Truman, James W
Cardona, Albert
Pankratz, Michael J
author_facet Miroschnikow, Anton
Schlegel, Philipp
Schoofs, Andreas
Hueckesfeld, Sebastian
Li, Feng
Schneider-Mizell, Casey M
Fetter, Richard D
Truman, James W
Cardona, Albert
Pankratz, Michael J
author_sort Miroschnikow, Anton
collection PubMed
description We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the CNS. Output neurons consist of feeding motor, serotonergic modulatory and neuroendocrine neurons. Monosynaptic connections from a set of sensory synaptic compartments cover the motor, modulatory and neuroendocrine targets in overlapping domains. Polysynaptic routes are superimposed on top of monosynaptic connections, resulting in divergent sensory paths that converge on common outputs. A completely different set of sensory compartments is connected to the mushroom body calyx. The mushroom body output neurons are connected to interneurons that directly target the feeding output neurons. Our results illustrate a circuit architecture in which monosynaptic and multisynaptic connections from sensory inputs traverse onto output neurons via a series of converging paths.
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spelling pubmed-62895732018-12-12 Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome Miroschnikow, Anton Schlegel, Philipp Schoofs, Andreas Hueckesfeld, Sebastian Li, Feng Schneider-Mizell, Casey M Fetter, Richard D Truman, James W Cardona, Albert Pankratz, Michael J eLife Neuroscience We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the CNS. Output neurons consist of feeding motor, serotonergic modulatory and neuroendocrine neurons. Monosynaptic connections from a set of sensory synaptic compartments cover the motor, modulatory and neuroendocrine targets in overlapping domains. Polysynaptic routes are superimposed on top of monosynaptic connections, resulting in divergent sensory paths that converge on common outputs. A completely different set of sensory compartments is connected to the mushroom body calyx. The mushroom body output neurons are connected to interneurons that directly target the feeding output neurons. Our results illustrate a circuit architecture in which monosynaptic and multisynaptic connections from sensory inputs traverse onto output neurons via a series of converging paths. eLife Sciences Publications, Ltd 2018-12-11 /pmc/articles/PMC6289573/ /pubmed/30526854 http://dx.doi.org/10.7554/eLife.40247 Text en © 2018, Miroschnikow et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Miroschnikow, Anton
Schlegel, Philipp
Schoofs, Andreas
Hueckesfeld, Sebastian
Li, Feng
Schneider-Mizell, Casey M
Fetter, Richard D
Truman, James W
Cardona, Albert
Pankratz, Michael J
Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
title Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
title_full Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
title_fullStr Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
title_full_unstemmed Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
title_short Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome
title_sort convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a drosophila feeding connectome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289573/
https://www.ncbi.nlm.nih.gov/pubmed/30526854
http://dx.doi.org/10.7554/eLife.40247
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