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ARIADNA: machine learning method for ancient DNA variant discovery

Ancient DNA (aDNA) studies often rely on standard methods of mutation calling, optimized for high-quality contemporary DNA but not for excessive contamination, time- or environment-related damage of aDNA. In the absence of validated datasets and despite showing extreme sensitivity to aDNA quality, t...

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Detalles Bibliográficos
Autores principales: Kawash, Joseph K, Smith, Sean D, Karaiskos, Spyros, Grigoriev, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289774/
https://www.ncbi.nlm.nih.gov/pubmed/30215675
http://dx.doi.org/10.1093/dnares/dsy029