Nd:YAG capsulotomy for the management of posterior capsular amyloidosis

PURPOSE: To describe the accumulation of amyloid in Berger's space. OBSERVATIONS: A 35-year-old man with autosomal-dominant, familial transthyretin-associated amyloidosis and bilateral vitreous opacities had a recurrence of amyloidosis following vitrectomy. The recurrent amyloid was attached to the posterior capsule of the lens. Phacoemulsification followed by neodymium:yttrium-aluminum-garnet (Nd:YAG) capsulotomy was helpful in restoring vision. CONCLUSIONS AND IMPORTANCE: Amyloid can reaccumulate in Berger's space, which is difficult to reach in phakic eyes during vitrectomy and can then cause decreased vision. Recognition of this interesting anatomic problem will allow for faster visual rehabilitation of the patient.