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Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review
BACKGROUND: Lymphomas are malignant neoplasms of the lymphocyte cell lines affecting the lymph nodes, spleen and other nonhemopoietic tissues. Of the extranodal lymphomas found in the head and neck region, 3–5% of malignant lymphomas arise in the oral and paraoral region, mainly from Waldeyer's...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289947/ https://www.ncbi.nlm.nih.gov/pubmed/30529948 http://dx.doi.org/10.1016/j.ijscr.2018.09.055 |
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author | Clarke, J. Medford, S. Islam, S. Ramsingh, C. Christopher, M. |
author_facet | Clarke, J. Medford, S. Islam, S. Ramsingh, C. Christopher, M. |
author_sort | Clarke, J. |
collection | PubMed |
description | BACKGROUND: Lymphomas are malignant neoplasms of the lymphocyte cell lines affecting the lymph nodes, spleen and other nonhemopoietic tissues. Of the extranodal lymphomas found in the head and neck region, 3–5% of malignant lymphomas arise in the oral and paraoral region, mainly from Waldeyer's ring. The involvement of the base of the tongue is extremely rare. SUMMARISED CASE: Case 1: 64 year old female who presented initially with an enlarged occipital lymph node which gradually became generalized cervical lymphadenopathy with initial histology confirmed reactive lymphoid hyperplasia. Biopsy of left postero-lateral tongue lesion eventually showed high grade T cell lymphoma. Case 2: 85 year old male presented with history of dysphagia for one year who was found to have a lesion extending from his base of tongue into the nasopharynx. Histology showed a diffuse B cell lymphoma. DISCUSSION: Both patients were noted to have lesion of the tongue, but tongue lesions are noted in the literature to be extremely rare. When tongue lymphomas do occur, most are of B-cell origin; the diffuse large-cell variety is the most common. Extranodal lymphomas of the T cell phenotype tend more to be sinonasal in origin than of the tongue, with T cell lymphomas of the tongue being even rarer than B cell lymphomas. CONCLUSION: With regards to tumours arising in the tongue, squamous cell carcinomas are still classified as the most common. Lymphomas however, should still be kept in consideration as a differential diagnosis with regards to lesions arising from this site. |
format | Online Article Text |
id | pubmed-6289947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-62899472018-12-17 Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review Clarke, J. Medford, S. Islam, S. Ramsingh, C. Christopher, M. Int J Surg Case Rep Article BACKGROUND: Lymphomas are malignant neoplasms of the lymphocyte cell lines affecting the lymph nodes, spleen and other nonhemopoietic tissues. Of the extranodal lymphomas found in the head and neck region, 3–5% of malignant lymphomas arise in the oral and paraoral region, mainly from Waldeyer's ring. The involvement of the base of the tongue is extremely rare. SUMMARISED CASE: Case 1: 64 year old female who presented initially with an enlarged occipital lymph node which gradually became generalized cervical lymphadenopathy with initial histology confirmed reactive lymphoid hyperplasia. Biopsy of left postero-lateral tongue lesion eventually showed high grade T cell lymphoma. Case 2: 85 year old male presented with history of dysphagia for one year who was found to have a lesion extending from his base of tongue into the nasopharynx. Histology showed a diffuse B cell lymphoma. DISCUSSION: Both patients were noted to have lesion of the tongue, but tongue lesions are noted in the literature to be extremely rare. When tongue lymphomas do occur, most are of B-cell origin; the diffuse large-cell variety is the most common. Extranodal lymphomas of the T cell phenotype tend more to be sinonasal in origin than of the tongue, with T cell lymphomas of the tongue being even rarer than B cell lymphomas. CONCLUSION: With regards to tumours arising in the tongue, squamous cell carcinomas are still classified as the most common. Lymphomas however, should still be kept in consideration as a differential diagnosis with regards to lesions arising from this site. Elsevier 2018-11-30 /pmc/articles/PMC6289947/ /pubmed/30529948 http://dx.doi.org/10.1016/j.ijscr.2018.09.055 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Clarke, J. Medford, S. Islam, S. Ramsingh, C. Christopher, M. Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
title | Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
title_full | Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
title_fullStr | Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
title_full_unstemmed | Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
title_short | Extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
title_sort | extranodal lymphoma of the tongue, a very rare entity-report of two cases with literature review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289947/ https://www.ncbi.nlm.nih.gov/pubmed/30529948 http://dx.doi.org/10.1016/j.ijscr.2018.09.055 |
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