Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

In this work, Ti—Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti—Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was emp...

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Detalles Bibliográficos
Autores principales: Ouyang, Sihui, Huang, Qianli, Liu, Yong, Ouyang, Zhengxiao, Liang, Luxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290127/
https://www.ncbi.nlm.nih.gov/pubmed/30560217
http://dx.doi.org/10.1016/j.bioactmat.2018.12.001
Descripción
Sumario:In this work, Ti—Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti—Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and Ti—Mg MMCs implants were embedded into the femur condyles. Results showed that Ti—Mg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around Ti—Mg implants than around Ti implants, indicating that more active new-bone formed around Ti—Mg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around Ti—Mg implants than that around Ti implants.

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