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ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease

Alzheimer's disease mouse models that overexpress amyloid precursor protein (APP) and presenilin 1 (PS1) form β-amyloid (Aβ) plaques, a hallmark Alzheimer's disease lesion. It has been assumed that the neuroinflammation, synaptic dysfunction, neurodegeneration, and cognitive impairment obs...

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Detalles Bibliográficos
Autores principales:	Sadleir, Katherine R., Popovic, Jelena, Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290164/ https://www.ncbi.nlm.nih.gov/pubmed/30315100 http://dx.doi.org/10.1074/jbc.RA118.005769

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