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Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma

AIM: This study aimed to observe the cyclooxygenase-2 expression and its correlation with tumour size and lymph node involvement in nasopharyngeal carcinoma. METHODS: This study was cross-sectional, that enrolled 126 samples diagnosed with nasopharyngeal carcinoma in Haji Adam Malik General Hospital...

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Autores principales: Chrestella, Jessy, Farhat, Farhat, Daulay, Elvita Rahmi, Asnir, Rizalina Arwinati, Yudhistira, Ashri, Nasution, Indah Afriani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290448/
https://www.ncbi.nlm.nih.gov/pubmed/30559850
http://dx.doi.org/10.3889/oamjms.2018.356
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author Chrestella, Jessy
Farhat, Farhat
Daulay, Elvita Rahmi
Asnir, Rizalina Arwinati
Yudhistira, Ashri
Nasution, Indah Afriani
author_facet Chrestella, Jessy
Farhat, Farhat
Daulay, Elvita Rahmi
Asnir, Rizalina Arwinati
Yudhistira, Ashri
Nasution, Indah Afriani
author_sort Chrestella, Jessy
collection PubMed
description AIM: This study aimed to observe the cyclooxygenase-2 expression and its correlation with tumour size and lymph node involvement in nasopharyngeal carcinoma. METHODS: This study was cross-sectional, that enrolled 126 samples diagnosed with nasopharyngeal carcinoma in Haji Adam Malik General Hospital, Medan, Indonesia which fulfilled the inclusion criteria. RESULTS: Based on this study, we found that the age peak incidence of nasopharyngeal carcinoma patients about a 41-60-year-old group (57.1%), dominated by men (71.4%). Through histopathological examination, non-keratinizing squamous cell carcinoma is the most predominant type (79.4%). We also found T3 is the most prevalent primary tumour size (32.5%) with prominent lymph node involvement N3 (45.2%), and stage IV (54.8%). Cyclooxygenase-2 overexpression is prevalent among nonkeratinizing squamous cell carcinoma (81.1%), T3 primary tumour size (41.1%), N3 node involvement (60.0%), and IV clinical stage (71.6%). In addition, we found a significant relationship between cyclooxygenase-2 expressions towards tumor size (p < 0.001) and lymph node involvement (p < 0.001) in nasopharyngeal carcinoma. CONCLUSION: It is proved that the overexpression of cyclooxygenase-2 will increase the susceptibility of nasopharyngeal carcinoma patients having advanced primary tumour size and lymph node involvement.
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spelling pubmed-62904482018-12-17 Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma Chrestella, Jessy Farhat, Farhat Daulay, Elvita Rahmi Asnir, Rizalina Arwinati Yudhistira, Ashri Nasution, Indah Afriani Open Access Maced J Med Sci Basic Science AIM: This study aimed to observe the cyclooxygenase-2 expression and its correlation with tumour size and lymph node involvement in nasopharyngeal carcinoma. METHODS: This study was cross-sectional, that enrolled 126 samples diagnosed with nasopharyngeal carcinoma in Haji Adam Malik General Hospital, Medan, Indonesia which fulfilled the inclusion criteria. RESULTS: Based on this study, we found that the age peak incidence of nasopharyngeal carcinoma patients about a 41-60-year-old group (57.1%), dominated by men (71.4%). Through histopathological examination, non-keratinizing squamous cell carcinoma is the most predominant type (79.4%). We also found T3 is the most prevalent primary tumour size (32.5%) with prominent lymph node involvement N3 (45.2%), and stage IV (54.8%). Cyclooxygenase-2 overexpression is prevalent among nonkeratinizing squamous cell carcinoma (81.1%), T3 primary tumour size (41.1%), N3 node involvement (60.0%), and IV clinical stage (71.6%). In addition, we found a significant relationship between cyclooxygenase-2 expressions towards tumor size (p < 0.001) and lymph node involvement (p < 0.001) in nasopharyngeal carcinoma. CONCLUSION: It is proved that the overexpression of cyclooxygenase-2 will increase the susceptibility of nasopharyngeal carcinoma patients having advanced primary tumour size and lymph node involvement. Republic of Macedonia 2018-11-19 /pmc/articles/PMC6290448/ /pubmed/30559850 http://dx.doi.org/10.3889/oamjms.2018.356 Text en Copyright: © 2018 Jessy Chrestella, Farhat Farhat, Elvita Rahmi Daulay, Rizalina Arwinati Asnir, Ashri Yudhistira, Indah Afriani Nasution. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Basic Science
Chrestella, Jessy
Farhat, Farhat
Daulay, Elvita Rahmi
Asnir, Rizalina Arwinati
Yudhistira, Ashri
Nasution, Indah Afriani
Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
title Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
title_full Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
title_fullStr Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
title_full_unstemmed Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
title_short Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
title_sort cyclooxygenase-2 expression and its correlation with primary tumor size and lymph node involvement in nasopharyngeal carcinoma
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290448/
https://www.ncbi.nlm.nih.gov/pubmed/30559850
http://dx.doi.org/10.3889/oamjms.2018.356
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