5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear. Because growing evidence suggested that the stimulation of proteases digesting Aβ, especially the endopeptidase neprilysin (N...

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Detalles Bibliográficos
Autores principales: Klein, Christian, Roussel, Guy, Brun, Susana, Rusu, Cristina, Patte-Mensah, Christine, Maitre, Michel, Mensah-Nyagan, Ayikoe-Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290545/
https://www.ncbi.nlm.nih.gov/pubmed/30537985
http://dx.doi.org/10.1186/s40478-018-0640-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290545/
https://www.ncbi.nlm.nih.gov/pubmed/30537985
http://dx.doi.org/10.1186/s40478-018-0640-z

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