Cargando…

Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study

AIMS/HYPOTHESIS: It has been shown that children previously enrolled in follow-up studies have better glycaemic control during the early period after diabetes diagnosis. The aim of this study was to analyse glycaemic control over a longer period, past the period of partial remission, after diagnosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Lundgren, Markus, Jonsdottir, Berglind, Elding Larsson, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290658/
https://www.ncbi.nlm.nih.gov/pubmed/30109365
http://dx.doi.org/10.1007/s00125-018-4706-z
_version_ 1783380132630626304
author Lundgren, Markus
Jonsdottir, Berglind
Elding Larsson, Helena
author_facet Lundgren, Markus
Jonsdottir, Berglind
Elding Larsson, Helena
author_sort Lundgren, Markus
collection PubMed
description AIMS/HYPOTHESIS: It has been shown that children previously enrolled in follow-up studies have better glycaemic control during the early period after diabetes diagnosis. The aim of this study was to analyse glycaemic control over a longer period, past the period of partial remission, after diagnosis in children followed before diagnosis in the Swedish Diabetes Prediction in Skåne (DiPiS) study compared with children of equal age not enrolled in pre-diabetes follow-up, receiving equivalent diabetes care. METHODS: HbA(1c) from diagnosis and for the following 5 years, as well as differences in insulin dosage, BMI, pump use, partial remission according to insulin dose-adjusted HbA(1c) and baseline demographics were compared between children who were enrolled in follow-up and had received information on diabetes risk (n = 51) and children not enrolled in follow-up (n = 78). RESULTS: The group followed before diagnosis had a higher proportion of first-degree relatives (FDRs) with diabetes (28% vs 5.6%; p = 0.001) and a higher proportion of participants with mothers born in Sweden (100% vs 89%; p = 0.02). No significant differences in total daily insulin dose, pump use or other baseline sociodemographic factors were detected between the groups. Median HbA(1c) at diagnosis and at 1, 2, 3, 4 and 5 years after diabetes diagnosis was significantly lower in children followed before diagnosis (all p < 0.05), and was not related to FDR status. CONCLUSIONS/INTERPRETATION: Compared with controls not previously enrolled in follow-up, our study shows that children enrolled in longitudinal follow-up before the diagnosis of diabetes have better glycaemic control, measured by HbA(1c), up to 5 years after diagnosis and during the initial period of partial remission. Improved glycaemic control in the initial years of living with type 1 diabetes could affect long-term outcome and complications and might also improve study enrolment in future longitudinal studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-018-4706-z) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
format Online
Article
Text
id pubmed-6290658
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-62906582018-12-27 Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study Lundgren, Markus Jonsdottir, Berglind Elding Larsson, Helena Diabetologia Short Communication AIMS/HYPOTHESIS: It has been shown that children previously enrolled in follow-up studies have better glycaemic control during the early period after diabetes diagnosis. The aim of this study was to analyse glycaemic control over a longer period, past the period of partial remission, after diagnosis in children followed before diagnosis in the Swedish Diabetes Prediction in Skåne (DiPiS) study compared with children of equal age not enrolled in pre-diabetes follow-up, receiving equivalent diabetes care. METHODS: HbA(1c) from diagnosis and for the following 5 years, as well as differences in insulin dosage, BMI, pump use, partial remission according to insulin dose-adjusted HbA(1c) and baseline demographics were compared between children who were enrolled in follow-up and had received information on diabetes risk (n = 51) and children not enrolled in follow-up (n = 78). RESULTS: The group followed before diagnosis had a higher proportion of first-degree relatives (FDRs) with diabetes (28% vs 5.6%; p = 0.001) and a higher proportion of participants with mothers born in Sweden (100% vs 89%; p = 0.02). No significant differences in total daily insulin dose, pump use or other baseline sociodemographic factors were detected between the groups. Median HbA(1c) at diagnosis and at 1, 2, 3, 4 and 5 years after diabetes diagnosis was significantly lower in children followed before diagnosis (all p < 0.05), and was not related to FDR status. CONCLUSIONS/INTERPRETATION: Compared with controls not previously enrolled in follow-up, our study shows that children enrolled in longitudinal follow-up before the diagnosis of diabetes have better glycaemic control, measured by HbA(1c), up to 5 years after diagnosis and during the initial period of partial remission. Improved glycaemic control in the initial years of living with type 1 diabetes could affect long-term outcome and complications and might also improve study enrolment in future longitudinal studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-018-4706-z) contains peer-reviewed but unedited supplementary material, which is available to authorised users. Springer Berlin Heidelberg 2018-08-14 2019 /pmc/articles/PMC6290658/ /pubmed/30109365 http://dx.doi.org/10.1007/s00125-018-4706-z Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Lundgren, Markus
Jonsdottir, Berglind
Elding Larsson, Helena
Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study
title Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study
title_full Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study
title_fullStr Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study
title_full_unstemmed Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study
title_short Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study
title_sort effect of screening for type 1 diabetes on early metabolic control: the dipis study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290658/
https://www.ncbi.nlm.nih.gov/pubmed/30109365
http://dx.doi.org/10.1007/s00125-018-4706-z
work_keys_str_mv AT lundgrenmarkus effectofscreeningfortype1diabetesonearlymetaboliccontrolthedipisstudy
AT jonsdottirberglind effectofscreeningfortype1diabetesonearlymetaboliccontrolthedipisstudy
AT eldinglarssonhelena effectofscreeningfortype1diabetesonearlymetaboliccontrolthedipisstudy
AT effectofscreeningfortype1diabetesonearlymetaboliccontrolthedipisstudy