Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance

PURPOSE: Tryptophan’s (Trp) unique hydrophobic and structural properties make it an important antigen binding motif when positioned in complementarity-determining regions (CDRs) of monoclonal antibodies (mAbs). Oxidation of Trp residues within the CDR can deleteriously impact antigen binding, partic...

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Detalles Bibliográficos
Autores principales: Hageman, Tyler, Wei, Hui, Kuehne, Patrick, Fu, Jinmei, Ludwig, Richard, Tao, Li, Leone, Anthony, Zocher, Marcel, Das, Tapan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290686/
https://www.ncbi.nlm.nih.gov/pubmed/30536043
http://dx.doi.org/10.1007/s11095-018-2545-8

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