A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

The H7N9 influenza virus causes high-mortality disease in humans but no effective therapeutics are available. Here we report a human monoclonal antibody, m826, that binds to H7 hemagglutinin (HA) and protects against H7N9 infection. m826 binds to H7N9 HA with subnanomolar affinity at acidic pH and 1...

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Detalles Bibliográficos
Autores principales: Yu, Fei, Song, He, Wu, Yanling, Chang, So Young, Wang, Lili, Li, Wei, Hong, Binbin, Xia, Shuai, Wang, Chunyu, Khurana, Surender, Feng, Yang, Wang, Yanping, Sun, Zhiwu, He, Biao, Hou, Dongni, Manischewitz, Jody, King, Lisa R., Song, Yuanlin, Min, Ji-Young, Golding, Hana, Ji, Xinhua, Lu, Lu, Jiang, Shibo, Dimitrov, Dimiter S., Ying, Tianlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290738/
https://www.ncbi.nlm.nih.gov/pubmed/28966056
http://dx.doi.org/10.1016/j.chom.2017.08.011

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