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The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release

Dihydrofolate reductase (DHFR) catalyzes the stereospecific reduction of 7,8-dihydrofolate (FH2) to (6s)-5,6,7,8-tetrahydrofolate (FH4) via hydride transfer from NADPH. The consensus Escherichia coli DHFR mechanism involves conformational changes between closed and occluded states occurring during t...

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Detalles Bibliográficos
Autores principales:	Cao, Hongnan, Gao, Mu, Zhou, Hongyi, Skolnick, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290769/ https://www.ncbi.nlm.nih.gov/pubmed/30564747 http://dx.doi.org/10.1038/s42003-018-0236-y

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