Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL...

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Detalles Bibliográficos
Autores principales: Campa, Carlo C., Silva, Rangel L., Margaria, Jean P., Pirali, Tracey, Mattos, Matheus S., Kraemer, Lucas R., Reis, Diego C., Grosa, Giorgio, Copperi, Francesca, Dalmarco, Eduardo M., Lima-Júnior, Roberto C. P., Aprile, Silvio, Sala, Valentina, Dal Bello, Federica, Prado, Douglas Silva, Alves-Filho, Jose Carlos, Medana, Claudio, Cassali, Geovanni D., Tron, Gian Cesare, Teixeira, Mauro M., Ciraolo, Elisa, Russo, Remo C., Hirsch, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290777/
https://www.ncbi.nlm.nih.gov/pubmed/30542075
http://dx.doi.org/10.1038/s41467-018-07698-6

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