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Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations
Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclona...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291075/ https://www.ncbi.nlm.nih.gov/pubmed/30540749 http://dx.doi.org/10.1371/journal.pone.0206579 |