Corticosteroid use and increased CXCR2 levels on leukocytes are associated with lumacaftor/ivacaftor discontinuation in cystic fibrosis patients homozygous for the F508del CFTR mutation

Cystic fibrosis (CF) is the most common life-shortening genetic disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Several current therapies aim at improving availability and/or function of the mutant CFTR proteins. The combination therapeutic...

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Detalles Bibliográficos
Autores principales: Pohl, Kerstin, Nichols, David P., Taylor-Cousar, Jennifer L., Saavedra, Milene T., Strand, Matthew J., Nick, Jerry A., Bratcher, Preston E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291130/
https://www.ncbi.nlm.nih.gov/pubmed/30540818
http://dx.doi.org/10.1371/journal.pone.0209026

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