Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce pathogenic IgG in autoimmune and alloimmune diseases. We document the antibody isolation and compare rozanolixizumab with the same variable region exp...

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Detalles Bibliográficos
Autores principales: Smith, Bryan, Kiessling, Andrea, Lledo-Garcia, Rocio, Dixon, Kate L., Christodoulou, Louis, Catley, Matthew C., Atherfold, Paul, D’Hooghe, Lena E., Finney, Helene, Greenslade, Kevin, Hailu, Hanna, Kevorkian, Lara, Lightwood, Daniel, Meier, Christoph, Munro, Rebecca, Qureshi, Omar, Sarkar, Kaushik, Shaw, Sophie P., Tewari, Roohi, Turner, Alison, Tyson, Kerry, West, Shauna, Shaw, Stevan, Brennan, Frank R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291300/
https://www.ncbi.nlm.nih.gov/pubmed/30130439
http://dx.doi.org/10.1080/19420862.2018.1505464

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