Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency

Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP...

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Autores principales: Zafeiriou, Zafeiris, Bianchini, Diletta, Chandler, Robert, Rescigno, Pasquale, Yuan, Wei, Carreira, Suzanne, Barrero, Maialen, Petremolo, Antonella, Miranda, Susana, Riisnaes, Ruth, Rodrigues, Daniel Nava, Gurel, Bora, Sumanasuriya, Semini, Paschalis, Alec, Sharp, Adam, Mateo, Joaquin, Tunariu, Nina, Chinnaiyan, Arul M., Pritchard, Colin C., Kelly, Kevin, de Bono, Johann S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291437/
https://www.ncbi.nlm.nih.gov/pubmed/30340782
http://dx.doi.org/10.1016/j.eururo.2018.09.048
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author Zafeiriou, Zafeiris
Bianchini, Diletta
Chandler, Robert
Rescigno, Pasquale
Yuan, Wei
Carreira, Suzanne
Barrero, Maialen
Petremolo, Antonella
Miranda, Susana
Riisnaes, Ruth
Rodrigues, Daniel Nava
Gurel, Bora
Sumanasuriya, Semini
Paschalis, Alec
Sharp, Adam
Mateo, Joaquin
Tunariu, Nina
Chinnaiyan, Arul M.
Pritchard, Colin C.
Kelly, Kevin
de Bono, Johann S.
author_facet Zafeiriou, Zafeiris
Bianchini, Diletta
Chandler, Robert
Rescigno, Pasquale
Yuan, Wei
Carreira, Suzanne
Barrero, Maialen
Petremolo, Antonella
Miranda, Susana
Riisnaes, Ruth
Rodrigues, Daniel Nava
Gurel, Bora
Sumanasuriya, Semini
Paschalis, Alec
Sharp, Adam
Mateo, Joaquin
Tunariu, Nina
Chinnaiyan, Arul M.
Pritchard, Colin C.
Kelly, Kevin
de Bono, Johann S.
author_sort Zafeiriou, Zafeiris
collection PubMed
description Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP)-ribose polymerase inhibition and platinum, has increased interest in the utilisation of these drugs against a subset of these diseases. Here in we report three patients with advanced castration-resistant PCa with HRD defects having exceptional responses to carboplatin.
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spelling pubmed-62914372019-01-01 Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency Zafeiriou, Zafeiris Bianchini, Diletta Chandler, Robert Rescigno, Pasquale Yuan, Wei Carreira, Suzanne Barrero, Maialen Petremolo, Antonella Miranda, Susana Riisnaes, Ruth Rodrigues, Daniel Nava Gurel, Bora Sumanasuriya, Semini Paschalis, Alec Sharp, Adam Mateo, Joaquin Tunariu, Nina Chinnaiyan, Arul M. Pritchard, Colin C. Kelly, Kevin de Bono, Johann S. Eur Urol Article Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP)-ribose polymerase inhibition and platinum, has increased interest in the utilisation of these drugs against a subset of these diseases. Here in we report three patients with advanced castration-resistant PCa with HRD defects having exceptional responses to carboplatin. Elsevier Science 2019-01 /pmc/articles/PMC6291437/ /pubmed/30340782 http://dx.doi.org/10.1016/j.eururo.2018.09.048 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zafeiriou, Zafeiris
Bianchini, Diletta
Chandler, Robert
Rescigno, Pasquale
Yuan, Wei
Carreira, Suzanne
Barrero, Maialen
Petremolo, Antonella
Miranda, Susana
Riisnaes, Ruth
Rodrigues, Daniel Nava
Gurel, Bora
Sumanasuriya, Semini
Paschalis, Alec
Sharp, Adam
Mateo, Joaquin
Tunariu, Nina
Chinnaiyan, Arul M.
Pritchard, Colin C.
Kelly, Kevin
de Bono, Johann S.
Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
title Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
title_full Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
title_fullStr Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
title_full_unstemmed Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
title_short Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
title_sort genomic analysis of three metastatic prostate cancer patients with exceptional responses to carboplatin indicating different types of dna repair deficiency
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291437/
https://www.ncbi.nlm.nih.gov/pubmed/30340782
http://dx.doi.org/10.1016/j.eururo.2018.09.048
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