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Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

OBJECTIVES: We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT)...

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Autores principales: Shirvani, Saba, Tokarczuk, Paweł, Statton, Ben, Quinlan, Marina, Berry, Alaine, Tomlinson, James, Weale, Peter, Kühn, Bernd, O’Regan, Declan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291439/
https://www.ncbi.nlm.nih.gov/pubmed/29992384
http://dx.doi.org/10.1007/s00330-018-5628-3
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author Shirvani, Saba
Tokarczuk, Paweł
Statton, Ben
Quinlan, Marina
Berry, Alaine
Tomlinson, James
Weale, Peter
Kühn, Bernd
O’Regan, Declan P.
author_facet Shirvani, Saba
Tokarczuk, Paweł
Statton, Ben
Quinlan, Marina
Berry, Alaine
Tomlinson, James
Weale, Peter
Kühn, Bernd
O’Regan, Declan P.
author_sort Shirvani, Saba
collection PubMed
description OBJECTIVES: We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T(1). METHODS: In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T(1) were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots. RESULTS: Inter-study correlation of whole-kidney RBF was good for both single-TI (r(2) = 0.90), and multi-TI ASL (r(2) = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T(1) of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant. CONCLUSIONS: Free-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge. KEY POINTS: • Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T. • This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T (1) during free breathing. • This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-018-5628-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-62914392018-12-27 Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge Shirvani, Saba Tokarczuk, Paweł Statton, Ben Quinlan, Marina Berry, Alaine Tomlinson, James Weale, Peter Kühn, Bernd O’Regan, Declan P. Eur Radiol Magnetic Resonance OBJECTIVES: We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T(1). METHODS: In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T(1) were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots. RESULTS: Inter-study correlation of whole-kidney RBF was good for both single-TI (r(2) = 0.90), and multi-TI ASL (r(2) = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T(1) of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant. CONCLUSIONS: Free-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge. KEY POINTS: • Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T. • This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T (1) during free breathing. • This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-018-5628-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-07-10 2019 /pmc/articles/PMC6291439/ /pubmed/29992384 http://dx.doi.org/10.1007/s00330-018-5628-3 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Magnetic Resonance
Shirvani, Saba
Tokarczuk, Paweł
Statton, Ben
Quinlan, Marina
Berry, Alaine
Tomlinson, James
Weale, Peter
Kühn, Bernd
O’Regan, Declan P.
Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge
title Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge
title_full Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge
title_fullStr Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge
title_full_unstemmed Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge
title_short Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge
title_sort motion-corrected multiparametric renal arterial spin labelling at 3 t: reproducibility and effect of vasodilator challenge
topic Magnetic Resonance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291439/
https://www.ncbi.nlm.nih.gov/pubmed/29992384
http://dx.doi.org/10.1007/s00330-018-5628-3
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