The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

STAT1 has a key role in the regulation of innate and adaptive immunity by inducing transcriptional changes in response to cytokines, such as all types of interferons (IFN). STAT1 exist as two splice isoforms, which differ in regard to the C-terminal transactivation domain (TAD). STAT1β lacks the C-t...

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Detalles Bibliográficos
Autores principales: Parrini, Matthias, Meissl, Katrin, Ola, Mojoyinola Joanna, Lederer, Therese, Puga, Ana, Wienerroither, Sebastian, Kovarik, Pavel, Decker, Thomas, Müller, Mathias, Strobl, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291510/
https://www.ncbi.nlm.nih.gov/pubmed/30574148
http://dx.doi.org/10.3389/fimmu.2018.02879

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