Cargando…

Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles

There is general agreement that the neuropathological processes leading to Alzheimer’s disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacini, Francesca, Sorrentino, Pierpaolo, Lardone, Anna, Rucco, Rosaria, Baselice, Fabio, Cavaliere, Carlo, Aiello, Marco, Orsini, Mario, Iavarone, Alessandro, Manzo, Valentino, Carotenuto, Anna, Granata, Carmine, Hillebrand, Arjan, Sorrentino, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291511/
https://www.ncbi.nlm.nih.gov/pubmed/30574086
http://dx.doi.org/10.3389/fnagi.2018.00400
_version_ 1783380262985400320
author Jacini, Francesca
Sorrentino, Pierpaolo
Lardone, Anna
Rucco, Rosaria
Baselice, Fabio
Cavaliere, Carlo
Aiello, Marco
Orsini, Mario
Iavarone, Alessandro
Manzo, Valentino
Carotenuto, Anna
Granata, Carmine
Hillebrand, Arjan
Sorrentino, Giuseppe
author_facet Jacini, Francesca
Sorrentino, Pierpaolo
Lardone, Anna
Rucco, Rosaria
Baselice, Fabio
Cavaliere, Carlo
Aiello, Marco
Orsini, Mario
Iavarone, Alessandro
Manzo, Valentino
Carotenuto, Anna
Granata, Carmine
Hillebrand, Arjan
Sorrentino, Giuseppe
author_sort Jacini, Francesca
collection PubMed
description There is general agreement that the neuropathological processes leading to Alzheimer’s disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 patients with amnestic Mild Cognitive Impairment (aMCI), a prodromal stage of AD, and 16 matched healthy control (HCs). Significant differences between the two groups were found in the theta band, which is associated with memory processes, in both temporal poles (TPs). In aMCI, the degree and betweenness centrality (BC) were lower in the left superior TP, whereas in the right middle TP the BC was higher. A statistically significant negative linear correlation was found between the BC of the left superior TP and a delayed recall score, a sensitive marker of the “hippocampal memory” deficit in early AD. Our results suggest that the TPs, which are involved early in AD pathology and belong to the memory circuitry, have an altered role in the functional network in aMCI.
format Online
Article
Text
id pubmed-6291511
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-62915112018-12-20 Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles Jacini, Francesca Sorrentino, Pierpaolo Lardone, Anna Rucco, Rosaria Baselice, Fabio Cavaliere, Carlo Aiello, Marco Orsini, Mario Iavarone, Alessandro Manzo, Valentino Carotenuto, Anna Granata, Carmine Hillebrand, Arjan Sorrentino, Giuseppe Front Aging Neurosci Neuroscience There is general agreement that the neuropathological processes leading to Alzheimer’s disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 patients with amnestic Mild Cognitive Impairment (aMCI), a prodromal stage of AD, and 16 matched healthy control (HCs). Significant differences between the two groups were found in the theta band, which is associated with memory processes, in both temporal poles (TPs). In aMCI, the degree and betweenness centrality (BC) were lower in the left superior TP, whereas in the right middle TP the BC was higher. A statistically significant negative linear correlation was found between the BC of the left superior TP and a delayed recall score, a sensitive marker of the “hippocampal memory” deficit in early AD. Our results suggest that the TPs, which are involved early in AD pathology and belong to the memory circuitry, have an altered role in the functional network in aMCI. Frontiers Media S.A. 2018-12-06 /pmc/articles/PMC6291511/ /pubmed/30574086 http://dx.doi.org/10.3389/fnagi.2018.00400 Text en Copyright © 2018 Jacini, Sorrentino, Lardone, Rucco, Baselice, Cavaliere, Aiello, Orsini, Iavarone, Manzo, Carotenuto, Granata, Hillebrand and Sorrentino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jacini, Francesca
Sorrentino, Pierpaolo
Lardone, Anna
Rucco, Rosaria
Baselice, Fabio
Cavaliere, Carlo
Aiello, Marco
Orsini, Mario
Iavarone, Alessandro
Manzo, Valentino
Carotenuto, Anna
Granata, Carmine
Hillebrand, Arjan
Sorrentino, Giuseppe
Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
title Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
title_full Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
title_fullStr Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
title_full_unstemmed Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
title_short Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
title_sort amnestic mild cognitive impairment is associated with frequency-specific brain network alterations in temporal poles
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291511/
https://www.ncbi.nlm.nih.gov/pubmed/30574086
http://dx.doi.org/10.3389/fnagi.2018.00400
work_keys_str_mv AT jacinifrancesca amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT sorrentinopierpaolo amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT lardoneanna amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT ruccorosaria amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT baselicefabio amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT cavalierecarlo amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT aiellomarco amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT orsinimario amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT iavaronealessandro amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT manzovalentino amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT carotenutoanna amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT granatacarmine amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT hillebrandarjan amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles
AT sorrentinogiuseppe amnesticmildcognitiveimpairmentisassociatedwithfrequencyspecificbrainnetworkalterationsintemporalpoles