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Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles
There is general agreement that the neuropathological processes leading to Alzheimer’s disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 pa...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291511/ https://www.ncbi.nlm.nih.gov/pubmed/30574086 http://dx.doi.org/10.3389/fnagi.2018.00400 |
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author | Jacini, Francesca Sorrentino, Pierpaolo Lardone, Anna Rucco, Rosaria Baselice, Fabio Cavaliere, Carlo Aiello, Marco Orsini, Mario Iavarone, Alessandro Manzo, Valentino Carotenuto, Anna Granata, Carmine Hillebrand, Arjan Sorrentino, Giuseppe |
author_facet | Jacini, Francesca Sorrentino, Pierpaolo Lardone, Anna Rucco, Rosaria Baselice, Fabio Cavaliere, Carlo Aiello, Marco Orsini, Mario Iavarone, Alessandro Manzo, Valentino Carotenuto, Anna Granata, Carmine Hillebrand, Arjan Sorrentino, Giuseppe |
author_sort | Jacini, Francesca |
collection | PubMed |
description | There is general agreement that the neuropathological processes leading to Alzheimer’s disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 patients with amnestic Mild Cognitive Impairment (aMCI), a prodromal stage of AD, and 16 matched healthy control (HCs). Significant differences between the two groups were found in the theta band, which is associated with memory processes, in both temporal poles (TPs). In aMCI, the degree and betweenness centrality (BC) were lower in the left superior TP, whereas in the right middle TP the BC was higher. A statistically significant negative linear correlation was found between the BC of the left superior TP and a delayed recall score, a sensitive marker of the “hippocampal memory” deficit in early AD. Our results suggest that the TPs, which are involved early in AD pathology and belong to the memory circuitry, have an altered role in the functional network in aMCI. |
format | Online Article Text |
id | pubmed-6291511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62915112018-12-20 Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles Jacini, Francesca Sorrentino, Pierpaolo Lardone, Anna Rucco, Rosaria Baselice, Fabio Cavaliere, Carlo Aiello, Marco Orsini, Mario Iavarone, Alessandro Manzo, Valentino Carotenuto, Anna Granata, Carmine Hillebrand, Arjan Sorrentino, Giuseppe Front Aging Neurosci Neuroscience There is general agreement that the neuropathological processes leading to Alzheimer’s disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 patients with amnestic Mild Cognitive Impairment (aMCI), a prodromal stage of AD, and 16 matched healthy control (HCs). Significant differences between the two groups were found in the theta band, which is associated with memory processes, in both temporal poles (TPs). In aMCI, the degree and betweenness centrality (BC) were lower in the left superior TP, whereas in the right middle TP the BC was higher. A statistically significant negative linear correlation was found between the BC of the left superior TP and a delayed recall score, a sensitive marker of the “hippocampal memory” deficit in early AD. Our results suggest that the TPs, which are involved early in AD pathology and belong to the memory circuitry, have an altered role in the functional network in aMCI. Frontiers Media S.A. 2018-12-06 /pmc/articles/PMC6291511/ /pubmed/30574086 http://dx.doi.org/10.3389/fnagi.2018.00400 Text en Copyright © 2018 Jacini, Sorrentino, Lardone, Rucco, Baselice, Cavaliere, Aiello, Orsini, Iavarone, Manzo, Carotenuto, Granata, Hillebrand and Sorrentino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Jacini, Francesca Sorrentino, Pierpaolo Lardone, Anna Rucco, Rosaria Baselice, Fabio Cavaliere, Carlo Aiello, Marco Orsini, Mario Iavarone, Alessandro Manzo, Valentino Carotenuto, Anna Granata, Carmine Hillebrand, Arjan Sorrentino, Giuseppe Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles |
title | Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles |
title_full | Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles |
title_fullStr | Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles |
title_full_unstemmed | Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles |
title_short | Amnestic Mild Cognitive Impairment Is Associated With Frequency-Specific Brain Network Alterations in Temporal Poles |
title_sort | amnestic mild cognitive impairment is associated with frequency-specific brain network alterations in temporal poles |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291511/ https://www.ncbi.nlm.nih.gov/pubmed/30574086 http://dx.doi.org/10.3389/fnagi.2018.00400 |
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