Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

Resistance to the lantibiotic nisin (NIS) arises readily in Staphylococcus aureus as a consequence of mutations in the nsaS gene, which encodes the sensor kinase of the NsaRS two-component regulatory system. Here we present a series of studies to establish how these mutational changes result in redu...

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Detalles Bibliográficos
Autores principales: Randall, Christopher P., Gupta, Arya, Utley-Drew, Bret, Lee, Siu Yi, Morrison-Williams, Genevieve, O’Neill, Alex J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291627/
https://www.ncbi.nlm.nih.gov/pubmed/30541781
http://dx.doi.org/10.1128/mSphereDirect.00633-18

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