N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model

We have previously reported that primary hippocampal neurons exposed to synaptotoxic amyloid beta oligomers (AβOs), which are likely causative agents of Alzheimer’s disease (AD), exhibit abnormal Ca(2+) signals, mitochondrial dysfunction and defective structural plasticity. Additionally, AβOs-expose...

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Detalles Bibliográficos
Autores principales: More, Jamileth, Galusso, Nadia, Veloso, Pablo, Montecinos, Luis, Finkelstein, José Pablo, Sanchez, Gina, Bull, Ricardo, Valdés, José Luis, Hidalgo, Cecilia, Paula-Lima, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291746/
https://www.ncbi.nlm.nih.gov/pubmed/30574085
http://dx.doi.org/10.3389/fnagi.2018.00399

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