Synthesis and Structure–Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90

[Image: see text] Herein, we describe the synthesis and structure–activity relationships of cyclic peptides designed to target heat shock protein 90 (Hsp90). Generating 19 compounds and evaluating their binding affinity reveals that increasing electrostatic interactions allows the compounds to bind...

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Detalles Bibliográficos
Autores principales: Rahimi, Marwa N., Buckton, Laura K., Zaiter, Samantha S., Kho, Jessica, Chan, Vickie, Guo, Aldwin, Konesan, Jenane, Kwon, SuHyeon, Lam, Lok K. O., Lawler, Michael F., Leong, Michael, Moldovan, Gabriel D., Neale, David A., Thornton, Gillian, McAlpine, Shelli R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291811/
https://www.ncbi.nlm.nih.gov/pubmed/30555625
http://dx.doi.org/10.1021/acsmedchemlett.7b00310

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