Cargando…

Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications

Opioid receptors are distributed throughout the central and peripheral nervous systems and on many nonneuronal cells. Therefore, opioid administration induces effects beyond analgesia. In the enteric nervous system (ENS), stimulation of µ-opioid receptors triggers several inhibitory responses that c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Streicher, John M., Bilsky, Edward J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291905/ https://www.ncbi.nlm.nih.gov/pubmed/28946783 http://dx.doi.org/10.1177/0897190017732263

Ejemplares similares

Methylnaltrexone: Peripherally Acting µ-Opioid Receptor Antagonist
por: Uritsky, Tanya J.
Publicado: (2019)

Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation
por: Floettmann, Eike, et al.
Publicado: (2017)

Blood–brain barrier: mechanisms governing permeability and interaction with peripherally acting μ-opioid receptor antagonists
por: Viscusi, Eugene R, et al.
Publicado: (2020)

Peripherally acting μ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy
por: Pergolizzi, Joseph V, et al.
Publicado: (2017)

Peripherally Acting μ-Opioid Receptor Antagonists in the Management of Postoperative Ileus: a Clinical Review
por: Chamie, Karim, et al.
Publicado: (2020)

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation
por: Kanemasa, Toshiyuki, et al.
Publicado: (2019)

Peripherally acting opioid receptor antagonists in pediatric patients
por: Nair, Abhijit
Publicado: (2018)

Efficacy and Safety of Peripherally Acting μ-Opioid Receptor Antagonist (PAMORAs) for the Management of Patients With Opioid-Induced Constipation: A Systematic Review
por: Rekatsina, Martina, et al.
Publicado: (2021)

Naloxegol: First oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation
por: Anantharamu, Tejus, et al.
Publicado: (2015)

The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety
por: Pergolizzi Jr, Joseph V, et al.
Publicado: (2020)

Opioid-induced Constipation: A Review of Health-related Quality of Life, Patient Burden, Practical Clinical Considerations, and the Impact of Peripherally Acting μ-Opioid Receptor Antagonists
por: Argoff, Charles E.
Publicado: (2020)

Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects
por: Moynihan, Humphrey A., et al.
Publicado: (2012)

μ Opioid receptor: novel antagonists and structural modeling
por: Kaserer, Teresa, et al.
Publicado: (2016)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
por: Puls, Kristina, et al.
Publicado: (2022)

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
por: Manglik, Aashish, et al.
Publicado: (2012)

Activation mechanism of the μ-opioid receptor by an allosteric modulator
por: Kaneko, Shun, et al.
Publicado: (2022)

Peripherally Acting Opioids in Orofacial Pain
por: Liu, Qing, et al.
Publicado: (2021)

Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist
por: Levy-Cooperman, N., et al.
Publicado: (2016)

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
por: Kliewer, A., et al.
Publicado: (2019)

Quantitative Detection of µ Opioid Receptor: Western Blot Analyses Using µ Opioid Receptor Knockout Mice
por: Kasai, Shinya, et al.
Publicado: (2011)

Human μ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine μ Opioid Receptor
por: Perez-Aguilar, Jose Manuel, et al.
Publicado: (2012)

Heteromerization of μ-opioid receptor and cholecystokinin B receptor through the third transmembrane domain of the μ-opioid receptor contributes to the anti-opioid effects of cholecystokinin octapeptide
por: Yang, Yin, et al.
Publicado: (2018)

Kinetics and Mechanism of Fentanyl Dissociation from the μ-Opioid Receptor
por: Mahinthichaichan, Paween, et al.
Publicado: (2021)

Therapeutic potential of long-acting opioids and opioid antagonists for SARS-CoV-2 infection
por: Eagleton, Marie, et al.
Publicado: (2021)

Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model
por: Yuan, Chun-Su, et al.
Publicado: (2009)

Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors
por: Bao, Fenghua, et al.
Publicado: (2018)

Targeting pain and inflammation by peripherally acting opioids
por: Stein, Christoph
Publicado: (2013)

Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions
por: Gudin, Jeffrey, et al.
Publicado: (2020)

μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors
por: Severino, Amie L., et al.
Publicado: (2020)

Pharmacological Profiles of Oligomerized μ-Opioid Receptors
por: Lee, Cynthia Wei-Sheng, et al.
Publicado: (2013)

μ-Opioid receptor desensitization: homologous or heterologous?
por: Llorente, Javier, et al.
Publicado: (2012)

Structural insights into μ-opioid receptor activation
por: Huang, Weijiao, et al.
Publicado: (2015)

How μ-Opioid Receptor Recognizes Fentanyl
por: Vo, Quynh N., et al.
Publicado: (2020)

How μ-Opioid Receptor Recognizes Fentanyl
por: Vo, Quynh N., et al.
Publicado: (2020)

How μ-opioid receptor recognizes fentanyl
por: Vo, Quynh N., et al.
Publicado: (2021)

Inhibition of Opioid Transmission at the μ-Opioid Receptor Prevents Both Food Seeking and Binge-Like Eating
por: Giuliano, Chiara, et al.
Publicado: (2012)

Development of a Bioavailable μ Opioid Receptor (MOPr) Agonist, δ Opioid Receptor (DOPr) Antagonist Peptide That Evokes Antinociception without Development of Acute Tolerance
por: Mosberg, Henry I., et al.
Publicado: (2014)

Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype
por: Ziauddeen, Hisham, et al.
Publicado: (2016)

Attenuation of cocaine and heroin seeking by μ-opioid receptor antagonism
por: Giuliano, Chiara, et al.
Publicado: (2013)

Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9f2f6chql026oan5ioo25t0hsp