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An Eye on the Wnt Inhibitory Factor Wif1
The coordinated interplay between extrinsic activating and repressing cell signaling molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is well exemplified by studies on the evolutionarily conserved Wnt signaling pathways. Tight temporal and spatial regulation of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292148/ https://www.ncbi.nlm.nih.gov/pubmed/30574494 http://dx.doi.org/10.3389/fcell.2018.00167 |
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author | Poggi, Lucia Casarosa, Simona Carl, Matthias |
author_facet | Poggi, Lucia Casarosa, Simona Carl, Matthias |
author_sort | Poggi, Lucia |
collection | PubMed |
description | The coordinated interplay between extrinsic activating and repressing cell signaling molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is well exemplified by studies on the evolutionarily conserved Wnt signaling pathways. Tight temporal and spatial regulation of Wnt signaling activity is required throughout lifetime, from maternal stages before gastrulation until and throughout adulthood. Outside cells, the action of numerous Wnt ligands is counteracted and fine-tuned by only a handful of well characterized secreted inhibitors, such as for instance Dickkopf, secreted Frizzled Related Proteins and Cerberus. Here, we give an overview of our current understanding of another secreted Wnt signaling antagonist, the Wnt inhibitory factor Wif1. Wif1 can directly interact with various Wnt ligands and inhibits their binding to membrane bound receptors. Epigenetic promoter methylation of Wif1, leading to silencing of its transcription and concomitant up-regulation of Wnt signaling, is a common feature during cancer progression. Furthermore, an increasing number of reports describe Wif1 involvement in regulating processes during embryonic development, which so far has not received as much attention. We will summarize our knowledge on Wif1 function and its mode of action with a particular focus on the zebrafish (Danio rerio). In addition, we highlight the potential of Wif1 research to understand and possibly influence mechanisms underlying eye diseases and regeneration. |
format | Online Article Text |
id | pubmed-6292148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62921482018-12-20 An Eye on the Wnt Inhibitory Factor Wif1 Poggi, Lucia Casarosa, Simona Carl, Matthias Front Cell Dev Biol Cell and Developmental Biology The coordinated interplay between extrinsic activating and repressing cell signaling molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is well exemplified by studies on the evolutionarily conserved Wnt signaling pathways. Tight temporal and spatial regulation of Wnt signaling activity is required throughout lifetime, from maternal stages before gastrulation until and throughout adulthood. Outside cells, the action of numerous Wnt ligands is counteracted and fine-tuned by only a handful of well characterized secreted inhibitors, such as for instance Dickkopf, secreted Frizzled Related Proteins and Cerberus. Here, we give an overview of our current understanding of another secreted Wnt signaling antagonist, the Wnt inhibitory factor Wif1. Wif1 can directly interact with various Wnt ligands and inhibits their binding to membrane bound receptors. Epigenetic promoter methylation of Wif1, leading to silencing of its transcription and concomitant up-regulation of Wnt signaling, is a common feature during cancer progression. Furthermore, an increasing number of reports describe Wif1 involvement in regulating processes during embryonic development, which so far has not received as much attention. We will summarize our knowledge on Wif1 function and its mode of action with a particular focus on the zebrafish (Danio rerio). In addition, we highlight the potential of Wif1 research to understand and possibly influence mechanisms underlying eye diseases and regeneration. Frontiers Media S.A. 2018-12-06 /pmc/articles/PMC6292148/ /pubmed/30574494 http://dx.doi.org/10.3389/fcell.2018.00167 Text en Copyright © 2018 Poggi, Casarosa and Carl. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Poggi, Lucia Casarosa, Simona Carl, Matthias An Eye on the Wnt Inhibitory Factor Wif1 |
title | An Eye on the Wnt Inhibitory Factor Wif1 |
title_full | An Eye on the Wnt Inhibitory Factor Wif1 |
title_fullStr | An Eye on the Wnt Inhibitory Factor Wif1 |
title_full_unstemmed | An Eye on the Wnt Inhibitory Factor Wif1 |
title_short | An Eye on the Wnt Inhibitory Factor Wif1 |
title_sort | eye on the wnt inhibitory factor wif1 |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292148/ https://www.ncbi.nlm.nih.gov/pubmed/30574494 http://dx.doi.org/10.3389/fcell.2018.00167 |
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