Cargando…
AGEP overlap induced by hydroxychloroquine: a case report and literature review
Acute Generalized Exanthematous Pustulosis (AGEP) is a rare drug reaction manifesting as pustular lesions with surrounding erythema following exposure. The disease is often self-limited and treatment is supportive. It may present in an atypical variant with vesicles that desquamate into erosions, wh...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292357/ https://www.ncbi.nlm.nih.gov/pubmed/30559945 http://dx.doi.org/10.1080/20009666.2018.1547089 |
_version_ | 1783380382218977280 |
---|---|
author | Mercogliano, Christopher Khan, Muhammad Lin, Catherine Mohanty, Elan Zimmerman, Ryan |
author_facet | Mercogliano, Christopher Khan, Muhammad Lin, Catherine Mohanty, Elan Zimmerman, Ryan |
author_sort | Mercogliano, Christopher |
collection | PubMed |
description | Acute Generalized Exanthematous Pustulosis (AGEP) is a rare drug reaction manifesting as pustular lesions with surrounding erythema following exposure. The disease is often self-limited and treatment is supportive. It may present in an atypical variant with vesicles that desquamate into erosions, which classifies the disease as an AGEP/SJS Overlap. This overlap syndrome can carry a substantial mortality rate and necessitate elevation in the level of care. Hydroxychloroquine has been implicated in cases of AGEP, and we present a case of AGEP/SJS overlap attributed to this common medication. Given the prevalence of drug eruptions, it is critical for the physicians to recognize and not overlook this rare and potentially fatal dermatological emergency. |
format | Online Article Text |
id | pubmed-6292357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-62923572018-12-17 AGEP overlap induced by hydroxychloroquine: a case report and literature review Mercogliano, Christopher Khan, Muhammad Lin, Catherine Mohanty, Elan Zimmerman, Ryan J Community Hosp Intern Med Perspect Case Report Acute Generalized Exanthematous Pustulosis (AGEP) is a rare drug reaction manifesting as pustular lesions with surrounding erythema following exposure. The disease is often self-limited and treatment is supportive. It may present in an atypical variant with vesicles that desquamate into erosions, which classifies the disease as an AGEP/SJS Overlap. This overlap syndrome can carry a substantial mortality rate and necessitate elevation in the level of care. Hydroxychloroquine has been implicated in cases of AGEP, and we present a case of AGEP/SJS overlap attributed to this common medication. Given the prevalence of drug eruptions, it is critical for the physicians to recognize and not overlook this rare and potentially fatal dermatological emergency. Taylor & Francis 2018-12-11 /pmc/articles/PMC6292357/ /pubmed/30559945 http://dx.doi.org/10.1080/20009666.2018.1547089 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Mercogliano, Christopher Khan, Muhammad Lin, Catherine Mohanty, Elan Zimmerman, Ryan AGEP overlap induced by hydroxychloroquine: a case report and literature review |
title | AGEP overlap induced by hydroxychloroquine: a case report and literature review |
title_full | AGEP overlap induced by hydroxychloroquine: a case report and literature review |
title_fullStr | AGEP overlap induced by hydroxychloroquine: a case report and literature review |
title_full_unstemmed | AGEP overlap induced by hydroxychloroquine: a case report and literature review |
title_short | AGEP overlap induced by hydroxychloroquine: a case report and literature review |
title_sort | agep overlap induced by hydroxychloroquine: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292357/ https://www.ncbi.nlm.nih.gov/pubmed/30559945 http://dx.doi.org/10.1080/20009666.2018.1547089 |
work_keys_str_mv | AT mercoglianochristopher agepoverlapinducedbyhydroxychloroquineacasereportandliteraturereview AT khanmuhammad agepoverlapinducedbyhydroxychloroquineacasereportandliteraturereview AT lincatherine agepoverlapinducedbyhydroxychloroquineacasereportandliteraturereview AT mohantyelan agepoverlapinducedbyhydroxychloroquineacasereportandliteraturereview AT zimmermanryan agepoverlapinducedbyhydroxychloroquineacasereportandliteraturereview |