Interleukin-33 Contributes Toward Loss of Tolerance by Promoting B-Cell-Activating Factor of the Tumor-Necrosis-Factor Family (BAFF)-Dependent Autoantibody Production

Breaking tolerance is a key event leading to autoimmunity, but the exact mechanisms responsible for this remain uncertain. Here we show that the alarmin IL-33 is able to drive the generation of autoantibodies through induction of the B cell survival factor BAFF. A temporary, short-term increase in I...

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Detalles Bibliográficos
Autores principales: Rose, William A., Okragly, Angela J., Hu, Ningjie N., Daniels, Montanea R., Martin, Andrea P., Koh, Yi Ting, Kikly, Kristine, Benschop, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292404/
https://www.ncbi.nlm.nih.gov/pubmed/30574145
http://dx.doi.org/10.3389/fimmu.2018.02871

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