Cargando…

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs). In clinical studies hydroxychloroquine (HCQ), the only clinically approved autophagy inhibitor, does not consistently inhibit autoph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baquero, Pablo, Dawson, Amy, Mukhopadhyay, Arunima, Kuntz, Elodie M., Mitchell, Rebecca, Olivares, Orianne, Ianniciello, Angela, Scott, Mary T., Dunn, Karen, Nicastri, Michael C., Winkler, Jeffrey D., Michie, Alison M., Ryan, Kevin M., Halsey, Christina, Gottlieb, Eyal, Keaney, Erin P., Murphy, Leon O., Amaravadi, Ravi K., Holyoake, Tessa L., Helgason, G. Vignir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292500/ https://www.ncbi.nlm.nih.gov/pubmed/30185934 http://dx.doi.org/10.1038/s41375-018-0252-4

Ejemplares similares

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells
por: Kuntz, Elodie M., et al.
Publicado: (2017)

The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought
por: Ianniciello, Angela, et al.
Publicado: (2018)

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells
por: Karvela, Maria, et al.
Publicado: (2016)

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
por: Rattigan, Kevin M., et al.
Publicado: (2023)

Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks
por: Pellicano, Francesca, et al.
Publicado: (2011)

A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells
por: Lee, Sooncheol, et al.
Publicado: (2020)

Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition
por: Mitchell, Rebecca, et al.
Publicado: (2017)

Folate metabolism: a re-emerging therapeutic target in haematological cancers
por: Zarou, Martha M., et al.
Publicado: (2021)

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
por: Pellicano, Francesca, et al.
Publicado: (2014)

Metabolism in stem cell–driven leukemia: parallels between hematopoiesis and immunity
por: Rattigan, Kevin M., et al.
Publicado: (2023)

Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
por: Nicastri, Michael C., et al.
Publicado: (2017)

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
por: Kinstrie, Ross, et al.
Publicado: (2020)

Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
por: Kinstrie, Ross, et al.
Publicado: (2020)

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
por: Rattigan, Kevin M, et al.
Publicado: (2023)

Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia
por: de Beauchamp, Lucie, et al.
Publicado: (2021)

Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches
por: Yang, Fei, et al.
Publicado: (2023)

The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission
por: Jeanpierre, Sandrine, et al.
Publicado: (2020)

Differentiated cytoplasmic granule formation in quiescent and non-quiescent cells upon chronological aging
por: Lee, Hsin-Yi, et al.
Publicado: (2016)

Serglycin in Quiescent and Proliferating Primary Endothelial Cells
por: Reine, Trine M., et al.
Publicado: (2015)

Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast
por: Mohammad, Karamat, et al.
Publicado: (2021)

CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS
por: Oruganti, S R, et al.
Publicado: (2017)

Can immunotherapy specifically target acute myeloid leukemic stem cells?
por: Snauwaert, Sylvia, et al.
Publicado: (2013)

Quiescent Fibroblasts Exhibit High Metabolic Activity
por: Lemons, Johanna M. S., et al.
Publicado: (2010)

Dynamics and structure of quiescent solar prominences
por: Priest, E
Publicado: (1988)

The Quiescent Period in Acute Abdominal Affections
Publicado: (1902)

On the collision of rods in a quiescent fluid
por: Słomka, Jonasz, et al.
Publicado: (2020)

Maintenance of quiescent oocytes by noradrenergic signals
por: Kim, Jeongho, et al.
Publicado: (2021)

The Epigenetic Regulation of Quiescent in Stem Cells
por: Radak, Mehran, et al.
Publicado: (2023)

The role of mitochondrial proteases in leukemic cells and leukemic stem cells
por: Mirali, Sara, et al.
Publicado: (2020)

Quiescent-Interval Single-Shot Magnetic Resonance Angiography
por: Saini, Aman, et al.
Publicado: (2018)

Low-Level Nanog Expression in the Regulation of Quiescent Endothelium
por: Baruah, Jugajyoti, et al.
Publicado: (2020)

Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells
por: Luna-Yolba, Raquel, et al.
Publicado: (2021)

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency
por: Rein, Avigail, et al.
Publicado: (2022)

Preclinical approaches in chronic myeloid leukemia: from cells to systems
por: Clarke, Cassie J., et al.
Publicado: (2017)

Effects of plant-derived anti-leukemic drugs on individualized leukemic cell population profiles in Egyptian patients
por: ABOUL-SOUD, MOURAD A. M., et al.
Publicado: (2016)

Adaptive Roles of SSY1 and SIR3 During Cycles of Growth and Starvation in Saccharomyces cerevisiae Populations Enriched for Quiescent or Nonquiescent Cells
por: Wloch-Salamon, Dominika M., et al.
Publicado: (2017)

A massive quiescent galaxy at redshift 4.658
por: Carnall, Adam C., et al.
Publicado: (2023)

Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities
por: Marchand, Tony, et al.
Publicado: (2021)

Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells
por: Sepp, Kristel, et al.
Publicado: (2019)

The Causes of Relapse in Quiescent Cases of Pulmonary Tuberculosis
por: Clarke, Brice R.
Publicado: (1948)

Cannot write session to /tmp/vufind_sessions/sess_likmlf0948bv5cfv06r5m7nf6e