Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

The SRP-Sec61 targeting/translocation pathway of eukaryotic cells targets nascent protein chains to the membrane of the endoplasmic reticulum. Using this machinery, secretory proteins are translocated across this membrane whereas membrane proteins are integrated into the lipid bilayer. One of the ke...

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Detalles Bibliográficos
Autores principales: Klein, Wolfgang, Rutz, Claudia, Eckhard, Jamina, Provinciael, Becky, Specker, Edgar, Neuenschwander, Martin, Kleinau, Gunnar, Scheerer, Patrick, von Kries, Jens-Peter, Nazaré, Marc, Vermeire, Kurt, Schülein, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292634/
https://www.ncbi.nlm.nih.gov/pubmed/30543669
http://dx.doi.org/10.1371/journal.pone.0208641

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