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Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery
PURPOSE: Examine the antiseptic effect of long-term low-concentration (0.3%) povidone-iodine (PI) before cataract surgery. SETTING: St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. DESIGN: Single-armed prospective clinical study. METHODS: Repeated measure of preoperative conjunc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292903/ https://www.ncbi.nlm.nih.gov/pubmed/30171195 http://dx.doi.org/10.1038/s41433-018-0198-9 |
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author | Wass, Simon Albrektsen, Grethe Ødegård, Maria Tjåland Sand, Mari Austeng, Dordi |
author_facet | Wass, Simon Albrektsen, Grethe Ødegård, Maria Tjåland Sand, Mari Austeng, Dordi |
author_sort | Wass, Simon |
collection | PubMed |
description | PURPOSE: Examine the antiseptic effect of long-term low-concentration (0.3%) povidone-iodine (PI) before cataract surgery. SETTING: St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. DESIGN: Single-armed prospective clinical study. METHODS: Repeated measure of preoperative conjunctival samples from 51 participants were obtained the day before surgery (T1), the day of surgery after treatment with ophthalmic NSAID (T2), and after additional treatment with low-concentration PI (T3) given by placing a pledget soaked in a mix of eye-drops in fornix inferior for 20 min. RESULTS: Before surgery, and before any type of treatment (T1), bacterial growth (≥5 BC) in the conjunctiva was identified in 36 (66.7%) of the participants. After treatment with ophthalmic NSAID (T2), and after additional treatment with low-concentration PI (T3), bacteria were identified in 31 (60.8%) and 12 (23.4%) participants, respectively. All except one of the participants with a measurable change from T2 to T3 (n = 31, 60.8% of total sample), experienced a decrease in number of bacterial colonies (BC) after treatment with low-concentration PI (96.8 vs. 3.2%, p < 0.001). A complete removal of bacteria was seen in 20 (n = 31, 64,5%) of the colonized participants after treatment with PI. CONCLUSIONS: Preoperative treatment with long-term, low-concentration PI applied via a depot device in fornix inferior, seem to be an easy and effective way to reduce the number of BC in the conjunctiva. |
format | Online Article Text |
id | pubmed-6292903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62929032018-12-14 Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery Wass, Simon Albrektsen, Grethe Ødegård, Maria Tjåland Sand, Mari Austeng, Dordi Eye (Lond) Article PURPOSE: Examine the antiseptic effect of long-term low-concentration (0.3%) povidone-iodine (PI) before cataract surgery. SETTING: St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. DESIGN: Single-armed prospective clinical study. METHODS: Repeated measure of preoperative conjunctival samples from 51 participants were obtained the day before surgery (T1), the day of surgery after treatment with ophthalmic NSAID (T2), and after additional treatment with low-concentration PI (T3) given by placing a pledget soaked in a mix of eye-drops in fornix inferior for 20 min. RESULTS: Before surgery, and before any type of treatment (T1), bacterial growth (≥5 BC) in the conjunctiva was identified in 36 (66.7%) of the participants. After treatment with ophthalmic NSAID (T2), and after additional treatment with low-concentration PI (T3), bacteria were identified in 31 (60.8%) and 12 (23.4%) participants, respectively. All except one of the participants with a measurable change from T2 to T3 (n = 31, 60.8% of total sample), experienced a decrease in number of bacterial colonies (BC) after treatment with low-concentration PI (96.8 vs. 3.2%, p < 0.001). A complete removal of bacteria was seen in 20 (n = 31, 64,5%) of the colonized participants after treatment with PI. CONCLUSIONS: Preoperative treatment with long-term, low-concentration PI applied via a depot device in fornix inferior, seem to be an easy and effective way to reduce the number of BC in the conjunctiva. Nature Publishing Group UK 2018-08-31 2018-12 /pmc/articles/PMC6292903/ /pubmed/30171195 http://dx.doi.org/10.1038/s41433-018-0198-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wass, Simon Albrektsen, Grethe Ødegård, Maria Tjåland Sand, Mari Austeng, Dordi Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
title | Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
title_full | Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
title_fullStr | Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
title_full_unstemmed | Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
title_short | Antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
title_sort | antiseptic effect of low-concentration povidone-iodine applied with a depot device in the conjunctiva before cataract surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292903/ https://www.ncbi.nlm.nih.gov/pubmed/30171195 http://dx.doi.org/10.1038/s41433-018-0198-9 |
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