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A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations

Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients in the early stage. We conducted this study to explore the...

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Autores principales: Liu, Shuang, Cheng, Yuqi, Xie, Zhongqi, Lai, Aiyun, Lv, Zhaoping, Zhao, Yueyin, Xu, Xiufeng, Luo, Chunrong, Yu, Hongjun, Shan, Baoci, Xu, Lin, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292957/
https://www.ncbi.nlm.nih.gov/pubmed/30581397
http://dx.doi.org/10.3389/fpsyt.2018.00677
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author Liu, Shuang
Cheng, Yuqi
Xie, Zhongqi
Lai, Aiyun
Lv, Zhaoping
Zhao, Yueyin
Xu, Xiufeng
Luo, Chunrong
Yu, Hongjun
Shan, Baoci
Xu, Lin
Xu, Jian
author_facet Liu, Shuang
Cheng, Yuqi
Xie, Zhongqi
Lai, Aiyun
Lv, Zhaoping
Zhao, Yueyin
Xu, Xiufeng
Luo, Chunrong
Yu, Hongjun
Shan, Baoci
Xu, Lin
Xu, Jian
author_sort Liu, Shuang
collection PubMed
description Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients in the early stage. We conducted this study to explore the possible brain activity changes using resting state functional magnetic resonance imaging (rs-fMRI) in SLE patients without major neuropsychiatric manifestations (non-NPSLE patients). We also tried to investigate the possible associations among brain activity, disease activity, depression, and anxiety. In our study, 118 non-NPSLE patients and 81 healthy controls (HC) were recruited. Rs-fMRI data were used to calculate the regional homogeneity (ReHo) in all participants. We found decreased ReHo values in the fusiform gyrus and thalamus and increased ReHo values in the parahippocampal gyrus and uncus. The disease activity was positively correlated with ReHo values of the cerebellum and negatively correlated with values in the frontal gyrus. Several brain areas showed correlations with depressive and anxiety statuses. These results suggested that abnormal brain activities might occur before NPSLE and might be the foundation of anxiety and depression symptoms. Early detection and proper treatment of brain dysfunction might prevent the progression to NPSLE. More studies are needed to understand the complicated underlying mechanisms.
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spelling pubmed-62929572018-12-21 A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations Liu, Shuang Cheng, Yuqi Xie, Zhongqi Lai, Aiyun Lv, Zhaoping Zhao, Yueyin Xu, Xiufeng Luo, Chunrong Yu, Hongjun Shan, Baoci Xu, Lin Xu, Jian Front Psychiatry Psychiatry Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients in the early stage. We conducted this study to explore the possible brain activity changes using resting state functional magnetic resonance imaging (rs-fMRI) in SLE patients without major neuropsychiatric manifestations (non-NPSLE patients). We also tried to investigate the possible associations among brain activity, disease activity, depression, and anxiety. In our study, 118 non-NPSLE patients and 81 healthy controls (HC) were recruited. Rs-fMRI data were used to calculate the regional homogeneity (ReHo) in all participants. We found decreased ReHo values in the fusiform gyrus and thalamus and increased ReHo values in the parahippocampal gyrus and uncus. The disease activity was positively correlated with ReHo values of the cerebellum and negatively correlated with values in the frontal gyrus. Several brain areas showed correlations with depressive and anxiety statuses. These results suggested that abnormal brain activities might occur before NPSLE and might be the foundation of anxiety and depression symptoms. Early detection and proper treatment of brain dysfunction might prevent the progression to NPSLE. More studies are needed to understand the complicated underlying mechanisms. Frontiers Media S.A. 2018-12-07 /pmc/articles/PMC6292957/ /pubmed/30581397 http://dx.doi.org/10.3389/fpsyt.2018.00677 Text en Copyright © 2018 Liu, Cheng, Xie, Lai, Lv, Zhao, Xu, Luo, Yu, Shan, Xu and Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Liu, Shuang
Cheng, Yuqi
Xie, Zhongqi
Lai, Aiyun
Lv, Zhaoping
Zhao, Yueyin
Xu, Xiufeng
Luo, Chunrong
Yu, Hongjun
Shan, Baoci
Xu, Lin
Xu, Jian
A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
title A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
title_full A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
title_fullStr A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
title_full_unstemmed A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
title_short A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
title_sort conscious resting state fmri study in sle patients without major neuropsychiatric manifestations
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292957/
https://www.ncbi.nlm.nih.gov/pubmed/30581397
http://dx.doi.org/10.3389/fpsyt.2018.00677
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