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Dysregulation of the Lateral Habenula in Major Depressive Disorder

Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in the development of psychiatric disorders including major depressive disorder (MDD). This discrete epithalamic nucleus acts as a relay hub linking forebrain limbic structures with midbrain aminergic center...

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Autores principales: Browne, Caroline A., Hammack, Robert, Lucki, Irwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292991/
https://www.ncbi.nlm.nih.gov/pubmed/30581384
http://dx.doi.org/10.3389/fnsyn.2018.00046
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author Browne, Caroline A.
Hammack, Robert
Lucki, Irwin
author_facet Browne, Caroline A.
Hammack, Robert
Lucki, Irwin
author_sort Browne, Caroline A.
collection PubMed
description Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in the development of psychiatric disorders including major depressive disorder (MDD). This discrete epithalamic nucleus acts as a relay hub linking forebrain limbic structures with midbrain aminergic centers. Central to reward processing, learning and goal directed behavior, the LHb has emerged as a critical regulator of the behaviors that are impaired in depression. Stress-induced activation of the LHb produces depressive- and anxiety-like behaviors, anhedonia and aversion in preclinical studies. Moreover, deep brain stimulation of the LHb in humans has been shown to alleviate chronic unremitting depression in treatment resistant depression. The diverse neurochemical processes arising in the LHb that underscore the emergence and treatment of MDD are considered in this review, including recent optogenetic studies that probe the anatomical connections of the LHb.
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spelling pubmed-62929912018-12-21 Dysregulation of the Lateral Habenula in Major Depressive Disorder Browne, Caroline A. Hammack, Robert Lucki, Irwin Front Synaptic Neurosci Neuroscience Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in the development of psychiatric disorders including major depressive disorder (MDD). This discrete epithalamic nucleus acts as a relay hub linking forebrain limbic structures with midbrain aminergic centers. Central to reward processing, learning and goal directed behavior, the LHb has emerged as a critical regulator of the behaviors that are impaired in depression. Stress-induced activation of the LHb produces depressive- and anxiety-like behaviors, anhedonia and aversion in preclinical studies. Moreover, deep brain stimulation of the LHb in humans has been shown to alleviate chronic unremitting depression in treatment resistant depression. The diverse neurochemical processes arising in the LHb that underscore the emergence and treatment of MDD are considered in this review, including recent optogenetic studies that probe the anatomical connections of the LHb. Frontiers Media S.A. 2018-12-07 /pmc/articles/PMC6292991/ /pubmed/30581384 http://dx.doi.org/10.3389/fnsyn.2018.00046 Text en Copyright © 2018 Browne, Hammack and Lucki. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Browne, Caroline A.
Hammack, Robert
Lucki, Irwin
Dysregulation of the Lateral Habenula in Major Depressive Disorder
title Dysregulation of the Lateral Habenula in Major Depressive Disorder
title_full Dysregulation of the Lateral Habenula in Major Depressive Disorder
title_fullStr Dysregulation of the Lateral Habenula in Major Depressive Disorder
title_full_unstemmed Dysregulation of the Lateral Habenula in Major Depressive Disorder
title_short Dysregulation of the Lateral Habenula in Major Depressive Disorder
title_sort dysregulation of the lateral habenula in major depressive disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292991/
https://www.ncbi.nlm.nih.gov/pubmed/30581384
http://dx.doi.org/10.3389/fnsyn.2018.00046
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