Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the...

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Autores principales: Edridge, Arthur W D, Deijs, Martin, Namazzi, Ruth, Cristella, Cosimo, Jebbink, Maarten F, Maurer, Irma, Kootstra, Neeltje A, Buluma, Linda R, van Woensel, Job B M, de Jong, Menno D, Idro, Richard, Boele van Hensbroek, Michael, van der Hoek, Lia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293039/
https://www.ncbi.nlm.nih.gov/pubmed/29893821
http://dx.doi.org/10.1093/cid/ciy486
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author Edridge, Arthur W D
Deijs, Martin
Namazzi, Ruth
Cristella, Cosimo
Jebbink, Maarten F
Maurer, Irma
Kootstra, Neeltje A
Buluma, Linda R
van Woensel, Job B M
de Jong, Menno D
Idro, Richard
Boele van Hensbroek, Michael
van der Hoek, Lia
author_facet Edridge, Arthur W D
Deijs, Martin
Namazzi, Ruth
Cristella, Cosimo
Jebbink, Maarten F
Maurer, Irma
Kootstra, Neeltje A
Buluma, Linda R
van Woensel, Job B M
de Jong, Menno D
Idro, Richard
Boele van Hensbroek, Michael
van der Hoek, Lia
author_sort Edridge, Arthur W D
collection PubMed
description A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.
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spelling pubmed-62930392018-12-19 Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy Edridge, Arthur W D Deijs, Martin Namazzi, Ruth Cristella, Cosimo Jebbink, Maarten F Maurer, Irma Kootstra, Neeltje A Buluma, Linda R van Woensel, Job B M de Jong, Menno D Idro, Richard Boele van Hensbroek, Michael van der Hoek, Lia Clin Infect Dis Brief Reports A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient. Oxford University Press 2019-01-01 2018-06-09 /pmc/articles/PMC6293039/ /pubmed/29893821 http://dx.doi.org/10.1093/cid/ciy486 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Edridge, Arthur W D
Deijs, Martin
Namazzi, Ruth
Cristella, Cosimo
Jebbink, Maarten F
Maurer, Irma
Kootstra, Neeltje A
Buluma, Linda R
van Woensel, Job B M
de Jong, Menno D
Idro, Richard
Boele van Hensbroek, Michael
van der Hoek, Lia
Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy
title Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy
title_full Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy
title_fullStr Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy
title_full_unstemmed Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy
title_short Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy
title_sort novel orthobunyavirus identified in the cerebrospinal fluid of a ugandan child with severe encephalopathy
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293039/
https://www.ncbi.nlm.nih.gov/pubmed/29893821
http://dx.doi.org/10.1093/cid/ciy486
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