Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Loss‐of‐function mutations in CDKL5 kinase cause severe neurodevelopmental delay and early‐onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates three microtubule‐associated proteins: MAP1S, EB2 and ARHGEF...

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Detalles Bibliográficos
Autores principales: Baltussen, Lucas L, Negraes, Priscilla D, Silvestre, Margaux, Claxton, Suzanne, Moeskops, Max, Christodoulou, Evangelos, Flynn, Helen R, Snijders, Ambrosius P, Muotri, Alysson R, Ultanir, Sila K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293278/
https://www.ncbi.nlm.nih.gov/pubmed/30266824
http://dx.doi.org/10.15252/embj.201899763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293278/
https://www.ncbi.nlm.nih.gov/pubmed/30266824
http://dx.doi.org/10.15252/embj.201899763

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