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The temporal expression patterns of brain transcriptome during chicken development and ageing

BACKGROUND: The transcriptional profiles of mammals during brain development and ageing have been characterized. However the global expression patterns of transcriptome in the chicken brain have not been explored. Here, we systematically investigated the temporal expression profiles of lncRNAs and m...

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Autores principales: Xu, Zhongxian, Che, Tiandong, Li, Feng, Tian, Kai, Zhu, Qing, Mishra, Shailendra Kumar, Dai, Yifei, Li, Mingzhou, Li, Diyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293534/
https://www.ncbi.nlm.nih.gov/pubmed/30545297
http://dx.doi.org/10.1186/s12864-018-5301-x
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author Xu, Zhongxian
Che, Tiandong
Li, Feng
Tian, Kai
Zhu, Qing
Mishra, Shailendra Kumar
Dai, Yifei
Li, Mingzhou
Li, Diyan
author_facet Xu, Zhongxian
Che, Tiandong
Li, Feng
Tian, Kai
Zhu, Qing
Mishra, Shailendra Kumar
Dai, Yifei
Li, Mingzhou
Li, Diyan
author_sort Xu, Zhongxian
collection PubMed
description BACKGROUND: The transcriptional profiles of mammals during brain development and ageing have been characterized. However the global expression patterns of transcriptome in the chicken brain have not been explored. Here, we systematically investigated the temporal expression profiles of lncRNAs and mRNAs across 8 stages (including 3 embryonic stages, 2 growth stages and 3 adult stages) in the female chicken cerebrum. RESULTS: We identified 39,907 putative lncRNAs and 14,558 mRNAs, investigated the temporal expression patterns by tracking a set of age-dependent genes and predicted potential biological functions of lncRNAs based on co-expression network. The results showed that genes with functions in development, synapses and axons exhibited a progressive decay; genes related to immune response were up-regulated with age. CONCLUSIONS: These results may reflect changes in the regulation of transcriptional networks and provide non-coding RNA gene candidates for further studies and would contribute to a comprehensive understanding of the molecular mechanisms of chicken development and may provide insights or deeper understanding regarding the regulatory mechanisms of age-dependent protein coding and non-protein coding genes in chicken. In addition, as the chicken is an important model organism bridging the evolutionary gap between mammals and other vertebrates, these high resolution data may provide a novel evidence to improve our comprehensive understanding of the brain transcriptome during vertebrate evolution. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-5301-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-62935342018-12-17 The temporal expression patterns of brain transcriptome during chicken development and ageing Xu, Zhongxian Che, Tiandong Li, Feng Tian, Kai Zhu, Qing Mishra, Shailendra Kumar Dai, Yifei Li, Mingzhou Li, Diyan BMC Genomics Research Article BACKGROUND: The transcriptional profiles of mammals during brain development and ageing have been characterized. However the global expression patterns of transcriptome in the chicken brain have not been explored. Here, we systematically investigated the temporal expression profiles of lncRNAs and mRNAs across 8 stages (including 3 embryonic stages, 2 growth stages and 3 adult stages) in the female chicken cerebrum. RESULTS: We identified 39,907 putative lncRNAs and 14,558 mRNAs, investigated the temporal expression patterns by tracking a set of age-dependent genes and predicted potential biological functions of lncRNAs based on co-expression network. The results showed that genes with functions in development, synapses and axons exhibited a progressive decay; genes related to immune response were up-regulated with age. CONCLUSIONS: These results may reflect changes in the regulation of transcriptional networks and provide non-coding RNA gene candidates for further studies and would contribute to a comprehensive understanding of the molecular mechanisms of chicken development and may provide insights or deeper understanding regarding the regulatory mechanisms of age-dependent protein coding and non-protein coding genes in chicken. In addition, as the chicken is an important model organism bridging the evolutionary gap between mammals and other vertebrates, these high resolution data may provide a novel evidence to improve our comprehensive understanding of the brain transcriptome during vertebrate evolution. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-5301-x) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-13 /pmc/articles/PMC6293534/ /pubmed/30545297 http://dx.doi.org/10.1186/s12864-018-5301-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Xu, Zhongxian
Che, Tiandong
Li, Feng
Tian, Kai
Zhu, Qing
Mishra, Shailendra Kumar
Dai, Yifei
Li, Mingzhou
Li, Diyan
The temporal expression patterns of brain transcriptome during chicken development and ageing
title The temporal expression patterns of brain transcriptome during chicken development and ageing
title_full The temporal expression patterns of brain transcriptome during chicken development and ageing
title_fullStr The temporal expression patterns of brain transcriptome during chicken development and ageing
title_full_unstemmed The temporal expression patterns of brain transcriptome during chicken development and ageing
title_short The temporal expression patterns of brain transcriptome during chicken development and ageing
title_sort temporal expression patterns of brain transcriptome during chicken development and ageing
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293534/
https://www.ncbi.nlm.nih.gov/pubmed/30545297
http://dx.doi.org/10.1186/s12864-018-5301-x
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