Impact of index hopping and bias towards the reference allele on accuracy of genotype calls from low-coverage sequencing

BACKGROUND: Inherent sources of error and bias that affect the quality of sequence data include index hopping and bias towards the reference allele. The impact of these artefacts is likely greater for low-coverage data than for high-coverage data because low-coverage data has scant information and m...

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Detalles Bibliográficos
Autores principales: Ros-Freixedes, Roger, Battagin, Mara, Johnsson, Martin, Gorjanc, Gregor, Mileham, Alan J., Rounsley, Steve D., Hickey, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293637/
https://www.ncbi.nlm.nih.gov/pubmed/30545283
http://dx.doi.org/10.1186/s12711-018-0436-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293637/
https://www.ncbi.nlm.nih.gov/pubmed/30545283
http://dx.doi.org/10.1186/s12711-018-0436-4

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