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Impact of index hopping and bias towards the reference allele on accuracy of genotype calls from low-coverage sequencing
BACKGROUND: Inherent sources of error and bias that affect the quality of sequence data include index hopping and bias towards the reference allele. The impact of these artefacts is likely greater for low-coverage data than for high-coverage data because low-coverage data has scant information and m...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293637/ https://www.ncbi.nlm.nih.gov/pubmed/30545283 http://dx.doi.org/10.1186/s12711-018-0436-4 |