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A high bioavailability and sustained-release nano-delivery system for nintedanib based on electrospray technology
BACKGROUND: Nintedanib is a new tyrosine kinase inhibitor and growth factor antagonist. It can be used to treat idiopathic pulmonary fibrosis diseases. Nintedanib has poor solubility in the intestinal tract environment, which leads to low bioavailability of just 4.7%. METHODS: In this study, a ninte...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294062/ https://www.ncbi.nlm.nih.gov/pubmed/30587966 http://dx.doi.org/10.2147/IJN.S181002 |