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Olaparib nanoparticles potentiated radiosensitization effects on lung cancer

BACKGROUND: Poly (ADP-ribose) polymerase (PARP) is a key enzyme in the repair process of DNA strand breaks (DSBs). Olaparib (Ola) is a PARP inhibitor that is involved in arresting PARP release from radiotherapy (RT)-induced damaged DNA to potentiate the effect of RT. Although the underlying mechanis...

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Detalles Bibliográficos
Autores principales:	Wu, Min, Liu, Jing, Hu, ChuanFei, Li, Dong, Yang, Juan, Wu, ZhouXue, Yang, LingLin, Chen, Yue, Fu, ShaoZhi, Wu, JingBo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294076/ https://www.ncbi.nlm.nih.gov/pubmed/30587971 http://dx.doi.org/10.2147/IJN.S181546

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