Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos

Aggresome-like induced structures (ALIS) have been described as ubiquitinated protein-containing aggresomes transiently formed in response to various stresses. In this study, we provide evidence that ALIS composed of SQSTM1/p62 act as a key determinant of oxidative stress-induced parthanatos, which...

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Detalles Bibliográficos
Autores principales: Noguchi, Takuya, Suzuki, Midori, Mutoh, Natsumi, Hirata, Yusuke, Tsuchida, Mei, Miyagawa, Sayoko, Hwang, Gi-Wook, Aoki, Junken, Matsuzawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294141/
https://www.ncbi.nlm.nih.gov/pubmed/30546061
http://dx.doi.org/10.1038/s41419-018-1245-y

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