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Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study

INTRODUCTION: Statin therapy is often associated with muscle complaints and increased serum creatine kinase (CK). However, although essential in determining muscle damage, this marker is not specific for skeletal muscle. Recent studies on animal models have shown that slow and fast isoforms of skele...

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Autores principales: Trentini, Alessandro, Spadaro, Savino, Rosta, Valentina, Manfrinato, Maria C, Cervellati, Carlo, Dalla Corte, Francesca, Hanau, Stefania, Volta, Carlo A, Bellini, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294157/
https://www.ncbi.nlm.nih.gov/pubmed/30591813
http://dx.doi.org/10.11613/BM.2019.010703
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author Trentini, Alessandro
Spadaro, Savino
Rosta, Valentina
Manfrinato, Maria C
Cervellati, Carlo
Dalla Corte, Francesca
Hanau, Stefania
Volta, Carlo A
Bellini, Tiziana
author_facet Trentini, Alessandro
Spadaro, Savino
Rosta, Valentina
Manfrinato, Maria C
Cervellati, Carlo
Dalla Corte, Francesca
Hanau, Stefania
Volta, Carlo A
Bellini, Tiziana
author_sort Trentini, Alessandro
collection PubMed
description INTRODUCTION: Statin therapy is often associated with muscle complaints and increased serum creatine kinase (CK). However, although essential in determining muscle damage, this marker is not specific for skeletal muscle. Recent studies on animal models have shown that slow and fast isoforms of skeletal troponin I (ssTnI and fsTnI, respectively) can be useful markers of skeletal muscle injury. The aim of this study was to evaluate the utility of ssTnI and fsTnI as markers to monitor the statin-induced skeletal muscle damage. MATERIALS AND METHODS: A total of 51 patients (14 using and 37 not using statins) admitted to the intensive care unit of the University of Ferrara Academic Hospital were included in this observational study. Serum activities of CK, aldolase, alanine aminotransferase and myoglobin were determined by spectrophotometric assays or routine laboratory analysis. Isoforms ssTnI and fsTnI were determined by commercially available ELISAs. The creatine kinase MB isoform (CK-MB) and cardiac troponin I (cTnI) were evaluated as biomarkers of cardiac muscle damage by automatic analysers. RESULTS: Among the non-specific markers, only CK was significantly higher in statin users (P = 0.027). Isoform fsTnI, but not ssTnI, was specifically increased in those patients using statins (P = 0.009) evidencing the major susceptibility of fast-twitch fibres towards statins. Sub-clinical increase in fsTnI, but not CK, was more frequent in statin users (P = 0.007). Cardiac markers were not significantly altered by statins confirming the selectivity of the effect on skeletal muscle. CONCLUSIONS: Serum fsTnI could be a good marker for monitoring statin-associated muscular damage outperforming traditional markers.
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spelling pubmed-62941572018-12-27 Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study Trentini, Alessandro Spadaro, Savino Rosta, Valentina Manfrinato, Maria C Cervellati, Carlo Dalla Corte, Francesca Hanau, Stefania Volta, Carlo A Bellini, Tiziana Biochem Med (Zagreb) Original Articles INTRODUCTION: Statin therapy is often associated with muscle complaints and increased serum creatine kinase (CK). However, although essential in determining muscle damage, this marker is not specific for skeletal muscle. Recent studies on animal models have shown that slow and fast isoforms of skeletal troponin I (ssTnI and fsTnI, respectively) can be useful markers of skeletal muscle injury. The aim of this study was to evaluate the utility of ssTnI and fsTnI as markers to monitor the statin-induced skeletal muscle damage. MATERIALS AND METHODS: A total of 51 patients (14 using and 37 not using statins) admitted to the intensive care unit of the University of Ferrara Academic Hospital were included in this observational study. Serum activities of CK, aldolase, alanine aminotransferase and myoglobin were determined by spectrophotometric assays or routine laboratory analysis. Isoforms ssTnI and fsTnI were determined by commercially available ELISAs. The creatine kinase MB isoform (CK-MB) and cardiac troponin I (cTnI) were evaluated as biomarkers of cardiac muscle damage by automatic analysers. RESULTS: Among the non-specific markers, only CK was significantly higher in statin users (P = 0.027). Isoform fsTnI, but not ssTnI, was specifically increased in those patients using statins (P = 0.009) evidencing the major susceptibility of fast-twitch fibres towards statins. Sub-clinical increase in fsTnI, but not CK, was more frequent in statin users (P = 0.007). Cardiac markers were not significantly altered by statins confirming the selectivity of the effect on skeletal muscle. CONCLUSIONS: Serum fsTnI could be a good marker for monitoring statin-associated muscular damage outperforming traditional markers. Croatian Society of Medical Biochemistry and Laboratory Medicine 2018-12-15 2019-02-15 /pmc/articles/PMC6294157/ /pubmed/30591813 http://dx.doi.org/10.11613/BM.2019.010703 Text en ©Croatian Society of Medical Biochemistry and Laboratory Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Trentini, Alessandro
Spadaro, Savino
Rosta, Valentina
Manfrinato, Maria C
Cervellati, Carlo
Dalla Corte, Francesca
Hanau, Stefania
Volta, Carlo A
Bellini, Tiziana
Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study
title Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study
title_full Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study
title_fullStr Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study
title_full_unstemmed Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study
title_short Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study
title_sort fast skeletal troponin i, but not the slow isoform, is increased in patients under statin therapy: a pilot study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294157/
https://www.ncbi.nlm.nih.gov/pubmed/30591813
http://dx.doi.org/10.11613/BM.2019.010703
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