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Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury
Treatment involving regenerative medicine for chronic spinal cord injury (SCI) is difficult due to phase-dependent changes in the intraspinal environment. We previously reported that treatment with a gamma-secretase inhibitor (GSI), which inhibits Notch signaling, promotes the differentiation into m...
Autores principales: | Okubo, Toshiki, Nagoshi, Narihito, Kohyama, Jun, Tsuji, Osahiko, Shinozaki, Munehisa, Shibata, Shinsuke, Kase, Yoshitaka, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294244/ https://www.ncbi.nlm.nih.gov/pubmed/30503258 http://dx.doi.org/10.1016/j.stemcr.2018.10.022 |
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