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Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how fates of individual vessels are determined. I...

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Autores principales: Weijts, Bart, Gutierrez, Edgar, Saikin, Semion K., Ablooglu, Ararat J., Traver, David, Groisman, Alex, Tkachenko, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294260/
https://www.ncbi.nlm.nih.gov/pubmed/30552331
http://dx.doi.org/10.1038/s41467-018-07732-7
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author Weijts, Bart
Gutierrez, Edgar
Saikin, Semion K.
Ablooglu, Ararat J.
Traver, David
Groisman, Alex
Tkachenko, Eugene
author_facet Weijts, Bart
Gutierrez, Edgar
Saikin, Semion K.
Ablooglu, Ararat J.
Traver, David
Groisman, Alex
Tkachenko, Eugene
author_sort Weijts, Bart
collection PubMed
description Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how fates of individual vessels are determined. In embryonic zebrafish trunk, vascular remodeling transforms arterial intersegmental vessels (ISVs) into a functional network of arteries and veins. Here we find that, once an ISV is connected to venous circulation, venous blood flow promotes upstream migration of ECs that results in displacement of arterial ECs by venous ECs, completing the transformation of this ISV into a vein without trans-differentiation of ECs. Arterial blood flow initiated in two neighboring ISVs prevents their transformation into veins by activating Notch signaling in ECs. Together, different responses of ECs to arterial and venous blood flow lead to formation of a balanced network with equal numbers of arteries and veins.
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spelling pubmed-62942602018-12-17 Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos Weijts, Bart Gutierrez, Edgar Saikin, Semion K. Ablooglu, Ararat J. Traver, David Groisman, Alex Tkachenko, Eugene Nat Commun Article Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and how fates of individual vessels are determined. In embryonic zebrafish trunk, vascular remodeling transforms arterial intersegmental vessels (ISVs) into a functional network of arteries and veins. Here we find that, once an ISV is connected to venous circulation, venous blood flow promotes upstream migration of ECs that results in displacement of arterial ECs by venous ECs, completing the transformation of this ISV into a vein without trans-differentiation of ECs. Arterial blood flow initiated in two neighboring ISVs prevents their transformation into veins by activating Notch signaling in ECs. Together, different responses of ECs to arterial and venous blood flow lead to formation of a balanced network with equal numbers of arteries and veins. Nature Publishing Group UK 2018-12-14 /pmc/articles/PMC6294260/ /pubmed/30552331 http://dx.doi.org/10.1038/s41467-018-07732-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Weijts, Bart
Gutierrez, Edgar
Saikin, Semion K.
Ablooglu, Ararat J.
Traver, David
Groisman, Alex
Tkachenko, Eugene
Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_full Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_fullStr Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_full_unstemmed Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_short Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_sort blood flow-induced notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294260/
https://www.ncbi.nlm.nih.gov/pubmed/30552331
http://dx.doi.org/10.1038/s41467-018-07732-7
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