Cargando…

Identification of new high affinity targets for Roquin based on structural conservation

Post-transcriptional gene regulation controls the amount of protein produced from a specific mRNA by altering both its decay and translation rates. Such regulation is primarily achieved by the interaction of trans-acting factors with cis-regulatory elements in the untranslated regions (UTRs) of mRNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braun, Johannes, Fischer, Sandra, Xu, Zhenjiang Z, Sun, Hongying, Ghoneim, Dalia H, Gimbel, Anna T, Plessmann, Uwe, Urlaub, Henning, Mathews, David H, Weigand, Julia E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294493/ https://www.ncbi.nlm.nih.gov/pubmed/30295819 http://dx.doi.org/10.1093/nar/gky908

Ejemplares similares

Structural basis for the recognition of transiently structured AU-rich elements by Roquin
por: Binas, Oliver, et al.
Publicado: (2020)

The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1
por: Sobańska, Daria, et al.
Publicado: (2022)

NMR-derived secondary structure of the full-length Ox40 mRNA 3′UTR and its multivalent binding to the immunoregulatory RBP Roquin
por: Tants, Jan-Niklas, et al.
Publicado: (2022)

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
por: Yildirim, Adem, et al.
Publicado: (2021)

Nearest neighbor rules for RNA helix folding thermodynamics: improved end effects
por: Zuber, Jeffrey, et al.
Publicado: (2022)

Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis
por: Naarmann-de Vries, Isabel S, et al.
Publicado: (2021)

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex
por: Yi, Sung-Hui, et al.
Publicado: (2022)

The SMAD3 transcription factor binds complex RNA structures with high affinity
por: Dickey, Thayne H., et al.
Publicado: (2017)

Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA
por: Maciej, Vincent D, et al.
Publicado: (2022)

Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes
por: Lavdovskaia, Elena, et al.
Publicado: (2020)

Expanding RNA binding specificity and affinity of engineered PUF domains
por: Zhao, Yang-Yang, et al.
Publicado: (2018)

Affinity proteomic dissection of the human nuclear cap-binding complex interactome
por: Dou, Yuhui, et al.
Publicado: (2020)

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA
por: Keil, Philipp, et al.
Publicado: (2022)

Insights into the evolutionary conserved regulation of Rio ATPase activity
por: Knüppel, Robert, et al.
Publicado: (2018)

An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb
por: Shortridge, Matthew D, et al.
Publicado: (2019)

High-affinity RNA targets of the Survival Motor Neuron protein reveal diverse preferences for sequence and structural motifs
por: Ottesen, Eric W, et al.
Publicado: (2018)

Efficient RNA pseudouridylation by eukaryotic H/ACA ribonucleoproteins requires high affinity binding and correct positioning of guide RNA
por: Caton, Evan A, et al.
Publicado: (2018)

Modeling RNA secondary structure folding ensembles using SHAPE mapping data
por: Spasic, Aleksandar, et al.
Publicado: (2018)

SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m(6)A-modified mRNAs
por: Hou, Guofang, et al.
Publicado: (2021)

Identification of conserved, primary sequence motifs that direct retrovirus RNA fate
por: Singh, Gatikrushna, et al.
Publicado: (2018)

Structural basis of successive adenosine modifications by the conserved ribosomal methyltransferase KsgA
por: Stephan, Niklas C, et al.
Publicado: (2021)

Eukaryotic tRNA sequences present conserved and amino acid-specific structural signatures
por: Westhof, Eric, et al.
Publicado: (2022)

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA
por: de Regt, Ann Kristin, et al.
Publicado: (2023)

Conserved structures formed by heterogeneous RNA sequences drive silencing of an inflammation responsive post-transcriptional operon
por: Basu, Abhijit, et al.
Publicado: (2017)

A conserved RNA structure is essential for a satellite RNA-mediated inhibition of helper virus accumulation
por: He, Lu, et al.
Publicado: (2019)

A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5′ splice site identity
por: Cartwright-Acar, Catiana H, et al.
Publicado: (2022)

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition
por: Tunnicliffe, Richard B, et al.
Publicado: (2019)

G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA
por: Simko, Eric A J, et al.
Publicado: (2020)

The conserved 3′ UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration
por: Wang, Chuan, et al.
Publicado: (2020)

PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2)
por: Landry-Voyer, Anne-Marie, et al.
Publicado: (2020)

The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex
por: Yeh, Chung-Shu, et al.
Publicado: (2017)

Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2
por: Sherpa, Chringma, et al.
Publicado: (2018)

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal
por: Glasser, Eliezra, et al.
Publicado: (2022)

Identification of clustered organellar short (cos) RNAs and of a conserved family of organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in the malaria parasite
por: Hillebrand, Arne, et al.
Publicado: (2018)

Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p
por: Imperatore, Joshua A, et al.
Publicado: (2021)

Initiating ribosomes and a 5′/3′-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation
por: Braun, Frédérique, et al.
Publicado: (2017)

Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection
por: Khoury, Georges, et al.
Publicado: (2020)

Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNA(Asn), tRNA(Gln), tRNA(Glu) and tRNA(Pro)
por: Jia, Zidong, et al.
Publicado: (2022)

At least two molecules of the RNA helicase Has1 are simultaneously present in pre-ribosomes during ribosome biogenesis
por: Gnanasundram, Sivakumar Vadivel, et al.
Publicado: (2019)

The low-resolution structural models of hepatitis C virus RNA subdomain 5BSL3.2 and its distal complex with domain 3′X point to conserved regulatory mechanisms within the Flaviviridae family
por: Castillo-Martínez, Jesús, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r63v2860hbkhrg9i17acq4kljn