Effect of in vivo post-translational modifications of the HMGB1 protein upon binding to platinated DNA: a molecular simulation study

Cisplatin is one of the most widely used anticancer drugs. Its efficiency is unfortunately severely hampered by resistance. The High Mobility Group Box (HMGB) proteins may sensitize tumor cells to cisplatin by specifically binding to platinated DNA (PtDNA) lesions. In vivo, the HMGB/PtDNA binding is...

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Detalles Bibliográficos
Autores principales: (Lv), Wenping Lyu, Arnesano, Fabio, Carloni, Paolo, Natile, Giovanni, Rossetti, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294504/
https://www.ncbi.nlm.nih.gov/pubmed/30407547
http://dx.doi.org/10.1093/nar/gky1082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294504/
https://www.ncbi.nlm.nih.gov/pubmed/30407547
http://dx.doi.org/10.1093/nar/gky1082

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