Single-nucleotide-resolution sequencing of human N(6)-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome

N (6)-methyldeoxyadenosine (6mA) is a well-characterized DNA modification in prokaryotes but reports on its presence and function in mammals have been controversial. To address this issue, we established the capacity of 6mA-Crosslinking-Exonuclease-sequencing (6mACE-seq) to detect genome-wide 6mA at...

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Detalles Bibliográficos
Autores principales: Koh, Casslynn W Q, Goh, Yeek Teck, Toh, Joel D W, Neo, Suat Peng, Ng, Sarah B, Gunaratne, Jayantha, Gao, Yong-Gui, Quake, Stephen R, Burkholder, William F, Goh, Wee Siong S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294517/
https://www.ncbi.nlm.nih.gov/pubmed/30412255
http://dx.doi.org/10.1093/nar/gky1104

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