CRISPR-C: circularization of genes and chromosome by CRISPR in human cells

Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations found in humans with genetic disorders. However, there is a lack of genetic engineering tools to recapitulate and study the biogenesis of eccDNAs. Here, we created a dual-fluorescence biosensor cassette, which upon t...

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Detalles Bibliográficos
Autores principales: Møller, Henrik Devitt, Lin, Lin, Xiang, Xi, Petersen, Trine Skov, Huang, Jinrong, Yang, Luhan, Kjeldsen, Eigil, Jensen, Uffe Birk, Zhang, Xiuqing, Liu, Xin, Xu, Xun, Wang, Jian, Yang, Huanming, Church, George M, Bolund, Lars, Regenberg, Birgitte, Luo, Yonglun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294522/
https://www.ncbi.nlm.nih.gov/pubmed/30551175
http://dx.doi.org/10.1093/nar/gky767

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