Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

Unresolved ER stress followed by cell death is recognized as the main cause of a multitude of pathologies including neonatal diabetes. A systematic analysis of the mechanisms of β-cell loss and dysfunction in Akita mice, in which a mutation in the proinsulin gene causes a severe form of permanent ne...

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Detalles Bibliográficos
Autores principales: Riahi, Yael, Israeli, Tal, Yeroslaviz, Roni, Chimenez, Shoshana, Avrahami, Dana, Stolovich-Rain, Miri, Alter, Ido, Sebag, Marina, Polin, Nava, Bernal-Mizrachi, Ernesto, Dor, Yuval, Cerasi, Erol, Leibowitz, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294551/
https://www.ncbi.nlm.nih.gov/pubmed/30412050
http://dx.doi.org/10.7554/eLife.38472

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