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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This results in increased ER-stress suggested to trigger beta-cell apoptosis. In humans, the mechanisms underlying beta-cell failure remain unclear...

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Detalles Bibliográficos
Autores principales:	Balboa, Diego, Saarimäki-Vire, Jonna, Borshagovski, Daniel, Survila, Mantas, Lindholm, Päivi, Galli, Emilia, Eurola, Solja, Ustinov, Jarkko, Grym, Heli, Huopio, Hanna, Partanen, Juha, Wartiovaara, Kirmo, Otonkoski, Timo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Stem Cells and Regenerative Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294552/ https://www.ncbi.nlm.nih.gov/pubmed/30412052 http://dx.doi.org/10.7554/eLife.38519

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